Genetic and stress influences on the prevalence of hypertension among hispanics/latinos in the hispanic community health study/study of latinos (HCHS/SOL).

IF 1.8 4区医学 Blood Pressure Pub Date : 2022-12-01 DOI:10.1080/08037051.2022.2091977

Liana K Preudhomme, Marc D Gellman, Nora Franceschini, Krista M Perreira, Lindsay E Fernández-Rhodes, Linda C Gallo, Carmen R Isasi, Sylvia Smoller, Sheila F Castañeda, Martha Daviglus, Christina Hutten, Richard S Cooper, Jianwen Cai, Neil Schneiderman, Maria M Llabre

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引用次数: 1

Abstract

Purpose: The current study examined the effects of chronic stress and a genetic risk score on the presence of hypertension and elevated systolic blood pressure and diastolic blood pressure among Hispanics/Latinos in the target population of Hispanic Community Health Study/Study of Latinos.

Materials and methods: Of the participants (N = 11,623) assessed during two clinic visits (Visit 1 2008-2013 & Visit 2 2014-2018), we analysed data from 7,429 adults (50.4% female), aged 18-74, who were genotyped and responded to chronic stress questionnaires. We calculated an unweighted genetic risk score using blood pressure increasing single nucleotide polymorphisms (SNPs) found to be generalisable to Hispanics/Latinos (10 SNPs). Linear and logistic regression models were used to estimate associations between chronic stress and genetic risk score and their interaction, with prevalent Visit 2 SBP or DBP, and hypertension, respectively. Models accounted for sampling weights, stratification, and cluster design.

Results: Chronic stress (adjusted OR = 1.18, 95%CI:1.15,1.22) and hypertension genetic risk score (adjusted OR = 1.04, 95%CI:1.01,1.07) were significantly associated with prevalent hypertension, but there was no significant interaction between the chronic stress and genetic risk score on hypertension (p = .49). genetic risk score (b = .32, 95%CI:.08, .55, R² = .02) and chronic stress (b = .45, 95%CI:.19, .72, R² = .11) were related to DBP, with no significant interaction (p = .62). Genetic risk score (b = .42, 95%CI:.08, .76, R² = .01) and chronic stress (b = .80, 95%CI:.34,1.26, R² = .11) were also related to SBP, with no significant interaction (p = .51).

Conclusion: Results demonstrate the utility of a genetic risk score for blood pressure and are consistent with literature suggesting chronic stress has a strong, direct association with elevated blood pressure among U.S. Hispanics/Latinos.

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西班牙裔社区健康研究/拉丁裔研究(HCHS/SOL)中遗传和应激对西班牙裔/拉丁裔高血压患病率的影响

目的:本研究在西班牙裔社区健康研究/拉丁裔研究的目标人群中，研究慢性应激和遗传风险评分对西班牙裔/拉丁裔高血压、收缩压和舒张压升高的影响。材料和方法:在两次临床访问(2008-2013年访问1和2014-2018年访问2)中评估的参与者(N = 11,623)中，我们分析了7,429名年龄在18-74岁的成年人(50.4%女性)的数据，他们对慢性压力问卷进行了基因分型并进行了回应。我们使用血压升高的单核苷酸多态性(SNPs)计算了未加权的遗传风险评分，发现西班牙裔/拉丁裔人(10个SNPs)普遍存在。使用线性和逻辑回归模型来估计慢性应激和遗传风险评分之间的关联及其相互作用，分别与流行的第2次就诊收缩压或舒张压和高血压有关。模型考虑了抽样权重、分层和聚类设计。结果:慢性应激(调整后OR = 1.18, 95%CI:1.15,1.22)和高血压遗传风险评分(调整后OR = 1.04, 95%CI:1.01,1.07)与高血压患病率显著相关，但慢性应激与高血压遗传风险评分之间无显著交互作用(p = 0.49)。遗传风险评分(b = 0.32, 95%CI:。08, 0.55, R2 = 0.02)和慢性应激(b = 0.45, 95%CI:。19、0.72,R2 = 0.11)与DBP相关，无显著交互作用(p = 0.62)。遗传风险评分(b = 0.42, 95%CI:。08, 0.76, R2 = 0.01)和慢性应激(b = 0.80, 95%CI: 0.34,1.26, R2 = 0.11)也与收缩压相关，但无显著交互作用(p = 0.51)。结论:研究结果证明了遗传风险评分对血压的效用，并与文献一致，表明慢性压力与美国西班牙裔/拉丁裔人的血压升高有强烈的直接联系。

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来源期刊

Blood Pressure Medicine-Cardiology and Cardiovascular Medicine

CiteScore

3.20

自引率

5.60%

发文量

期刊介绍： For outstanding coverage of the latest advances in hypertension research, turn to Blood Pressure, a primary source for authoritative and timely information on all aspects of hypertension research and management. Features include: • Physiology and pathophysiology of blood pressure regulation • Primary and secondary hypertension • Cerebrovascular and cardiovascular complications of hypertension • Detection, treatment and follow-up of hypertension • Non pharmacological and pharmacological management • Large outcome trials in hypertension.