Effects of Transcranial Direct Current Stimulation on Memory of Elderly People with Mild Cognitive Impairment or Alzheimer's Disease: A Systematic Review.
Eliclebysson Rodrigo da Silva, Italo Ramon Rodrigues Menezes, Ivani Brys
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引用次数: 3
Abstract
Background: Transcranial direct current stimulation (tDCS) is one of the most studied non-invasive neuromodulation techniques, presenting itself as a promising technique for several pathologies, such as cognitive decline.
Objectives: The aim of this study was to conduct a systematic review of the effects of tDCS on the memory of elderly people with mild cognitive impairment or Alzheimer's disease, in order to describe the main protocols used, and to investigate the therapeutic effectiveness of this technique.
Data sources and methods: 869 studies reporting controlled clinical trials were found in the databases PubMed, Web of Science, Lilacs, PsycArticles and Scielo, from which 13 met the expected requirements and were included in the final analysis.
Results: There was a great variability in the stimulation protocols used in the studies; and methodological weaknesses were observed, such as absence of sample size calculation, and of information on effect sizes. Positive effects of tDCS were observed only in five studies, and the combination of stimulation and cognitive training did not seem to potentiate the effects of tDCS.
Conclusion: Although tDCS can be considered a technique with important therapeutic potential, more studies are needed to understand the acute effects of tDCS on memory of elderly people and the durability of these effects over time.
背景:经颅直流电刺激(tDCS)是研究最多的非侵入性神经调节技术之一，在治疗认知能力下降等多种疾病方面表现出良好的前景。目的:本研究的目的是对tDCS对轻度认知障碍或阿尔茨海默病老年人记忆的影响进行系统回顾，以描述所使用的主要方案，并探讨该技术的治疗效果。数据来源和方法:在PubMed、Web of Science、Lilacs、PsycArticles和Scielo数据库中共检索到869篇报告对照临床试验的研究，其中13篇符合预期要求，纳入最终分析。结果:在研究中使用的刺激方案有很大的可变性;研究还发现了方法上的缺陷，如缺乏样本量计算和效应量信息。仅在五项研究中观察到tDCS的积极作用，并且刺激和认知训练的结合似乎并没有增强tDCS的作用。结论:虽然tDCS可以被认为是一种具有重要治疗潜力的技术，但需要更多的研究来了解tDCS对老年人记忆的急性影响及其随时间的持久性。注册号:PROSPERO (CRD-42020200573)。
期刊介绍：
ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications.
The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.
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