Comparison of the impact of laser-assisted hatching on fresh cleavage and blastocyst embryo transfer and association with pregnancy outcomes.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-06-27 DOI:10.4274/tjod.galenos.2022.36690

Selin Hazır, İskender Kaplanoğlu, Asena Ayça Özdemir, Oya Aldemir, Runa Özelci, İnci Kahyaoğlu, Serdar Dilbaz

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引用次数: 1

Abstract

Objective: Assisted hatching (AH) techniques can improve live birth (LB) and clinical pregnancy (CP) rates. Since there are limited data regarding this subject, we investigated the impact of laser-assisted hatching (LAH) on fresh embryo transfer (ET) and association with pregnancy outcomes in unselected patient population.

Materials and methods: This retrospective study included the fresh ETs performed at our center between April 2010 and April 2019. Among 3.782 fresh ETs, 3.286 underwent LAH (n=1.583 at cleavage stage and n=1.703 at blastocyst stage) while 496 underwent non-assisted hatching (NAH) (n=213 at cleavage stage and n=283 at blastocyst stage). The ETs were performed at the blastocyst or cleavage stages, and single or double embryos were transferred. LB rate was the primary outcome, while secondary outcomes were the pregnancy test, monozygotic twinning (MZT), and CP rates.

Results: The LAH and NAH groups showed similar LB, pregnancy test, CP, and MZT rates at cleavage and blastocyst stages. On the other hand, LAH significantly affected LB rates at the blastocyst stage (20.6% at blastocyst stage vs. 16% at the cleavage stage, p=0.001).

Conclusion: In conclusion, LAH does not improve reproductive outcomes of fresh blastocyst-stage and cleavage-stage ETs. However, LAH significant impacts LB rates in the blastocyst stage than the cleavage stage.

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激光辅助孵化对新鲜卵裂和囊胚移植的影响及其与妊娠结局的关系。

目的:辅助孵化(AH)技术可提高活产(LB)和临床妊娠(CP)率。由于这方面的数据有限，我们在未选择的患者群体中研究了激光辅助孵化(LAH)对新鲜胚胎移植(ET)的影响及其与妊娠结局的关系。材料和方法:本回顾性研究包括2010年4月至2019年4月在本中心进行的新鲜et。在3.782个新鲜et中，有3.286个进行了体外孵化(卵裂期为1.583，囊胚期为1.703)，496个进行了非辅助孵化(卵裂期为213，囊胚期为283)。胚胎移植在囊胚期或卵裂期进行，单胚胎或双胚胎移植。LB率是主要结果，而次要结果是妊娠试验、单卵双胞胎(MZT)和CP率。结果:LAH组和NAH组在卵裂期和囊胚期的LB、妊娠试验、CP和MZT率相似。另一方面，LAH显著影响囊胚期的LB率(囊胚期20.6%，卵裂期16%，p=0.001)。结论:LAH对新鲜囊胚期和卵裂期et的生殖结局没有改善作用。然而，与卵裂期相比，LAH对囊胚期LB率的影响更大。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.