Anisotropy of Transverse Spin Relaxation in H₂O-D₂O Liquid Entrapped in Nanocavities: Application to Studies of Connective Tissues.

Q3 Physics and Astronomy Hyperfine Interactions Pub Date : 2021-12-01 Epub Date: 2021-10-30 DOI:10.1007/s10751-021-01731-9

Gregory Furman, Victor Meerovich, Danil Petrov, Vladimir Sokolovsky, Yang Xia

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Abstract

The spin-spin relaxation in connective tissues is simulated using a model in which a connective tissue is represented by a set of nanocavities containing H₂O-D₂O liquid. Collagen fibrils in connective tissues form ordered hierarchical long structures of hydrated nano-cavities with characteristic diameter from 1 nm to several tens of nanometers and length of about 100 nm. We consider influence of the restricted Brownian motion of molecules inside a nano-cavity on spin-spin relaxation. The analytical expression for the transverse time T ₂ for H₂O-D₂O liquid in contained a nanocavity was obtained. We show that the angular dependence of the transverse relaxation rate does not depend on the concentration of D₂O. The theoretical results could explain the experimentally observed dependence of the degree of deuteration on the relaxation time T ₂. Accounting the orientation distribution of the nanocavities well agreement with the experimental dependence of the relaxation for articular cartilage on the deuteration degree was obtained.

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纳米空腔中H2O-D2O液体横向自旋弛豫的各向异性:在结缔组织研究中的应用。

用一组含有H2O-D2O液体的纳米空腔来表示结缔组织，模拟了结缔组织中的自旋弛豫。结缔组织中的胶原原纤维形成有序、分层的水合纳米空腔，其特征直径从1纳米到几十纳米，长度约为100纳米。考虑了纳米腔内分子的受限布朗运动对自旋弛豫的影响。得到了含有纳米空腔的H2O-D2O液体横向时间t2的解析表达式。我们发现横向弛豫速率的角依赖性不取决于D2O的浓度。理论结果可以解释实验观察到的氘化程度对弛豫时间t2的依赖性。计算了纳米空腔的取向分布，得到了关节软骨弛豫与氘化度的依赖关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Hyperfine Interactions Physics and Astronomy-Nuclear and High Energy Physics

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期刊介绍： Hyperfine Interactions is an international journal devoted to research in the border regions of Solid-State Physics, Atomic Physics, Nuclear Physics and relevant Chemistry. The interactions of atoms, ions, electrons and nuclei with their environments in solids, liquids, gases, plasmas and directed beams comprise a broad area of physical science in themselves and also prove unique tools for studies of the behaviour of many physical, chemical and biological systems.