Anti-Toxoplasma Activities of Some Egyptian Plant Extracts: An In Vitro Study

IF 1.2 3区农林科学 Q4 PARASITOLOGY Acta Parasitologica Pub Date : 2022-10-30 DOI:10.1007/s11686-022-00633-2

Sara T. Elazab, Fadwa M. Arafa

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Abstract

Purpose

Toxoplasmosis is a globally widespread parasitic disease which causes major health problems in human and animals. This research was conducted to assess the effect of some Egyptian herbal extracts against Toxoplasma gondii (T. gondii) tachyzoites in vitro.

Methods

The methanol extracts of Withania somnifera, Cyper rotundus, Acacia nilotica, Chrysanthemum cinerariae folium, Anethum graveolens, Raphanus sativus, Ceratonia siliqua, Elettaria cardamomum and Cuminum cyminum were tested against T. gondii tachyzoites.

Results

Among the tested plants, the extracts from Raphanus sativus, Cuminum cyminum, and Ceratonia siliqua exhibited high anti-Toxoplasma activities at 50 µg/ml, relative to sulfadiazine. They showed low IC₅₀ values on T. gondii (7.92, 9.47 and 13.52 µg/ml, respectively) and high selectivity index values (100.79, 59.19, and 29.05, respectively). Scanning electron microscopy (SEM) findings indicated evident morphological changes in tachyzoites treated with these three herbal extracts.

Conclusion

Raphanus sativus, Ceratonia siliqua, and Cuminum cyminum methanol extracts could be promising sources of new medicament for toxoplasmosis.

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一些埃及植物提取物抗弓形虫活性的体外研究

目的弓形虫病是一种全球广泛传播的寄生虫病，对人类和动物造成重大健康问题。本文研究了几种埃及草药提取物对刚地弓形虫速殖子的体外抑制作用。方法对苦参、黄柏、金合欢、金菊、白花菊、白花菊、大白菜、金银花、豆角蒿、小茴香甲醇提取物进行抗弓形虫速殖子试验。结果实验植物Raphanus sativus、Cuminum cyminum和Ceratonia siliqua提取物的抗弓形虫活性为50µg/ml，相对于磺胺嘧啶具有较高的抗虫活性。对弓形虫的IC50值较低(分别为7.92、9.47和13.52µg/ml)，选择性指数较高(分别为100.79、59.19和29.05)。扫描电镜(SEM)结果表明，三种草药提取物处理过的速殖子有明显的形态变化。结论萝卜、赤角菊和茴香甲醇提取物是治疗弓形虫病的有前景的新药。

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来源期刊

Acta Parasitologica 医学-寄生虫学

CiteScore

3.10

自引率

6.70%

发文量

149

审稿时长

6-12 weeks

期刊介绍： Acta Parasitologica is an international journal covering the latest advances in the subject. Acta Parasitologica publishes original papers on all aspects of parasitology and host-parasite relationships, including the latest discoveries in biochemical and molecular biology of parasites, their physiology, morphology, taxonomy and ecology, as well as original research papers on immunology, pathology, and epidemiology of parasitic diseases in the context of medical, veterinary and biological sciences. The journal also publishes short research notes, invited review articles, book reviews. The journal was founded in 1953 as "Acta Parasitologica Polonica" by the Polish Parasitological Society and since 1954 has been published by W. Stefanski Institute of Parasitology of the Polish Academy of Sciences in Warsaw. Since 1992 in has appeared as Acta Parasitologica in four issues per year.