DOG-1 positive primary acinic cell carcinoma of the lung and investigation of molecular status.

IF 4.4 Q1 PATHOLOGY PATHOLOGICA Pub Date : 2022-10-01 DOI:10.32074/1591-951X-786
Lorenzo Nibid, Luca Frasca, Giovanna Sabarese, Daniela Righi, Silvia Taccogna, Pierfilippo Crucitti, Paolo Graziano, Giuseppe Perrone
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引用次数: 2

Abstract

Primary acinic cell carcinoma (ACC) of the lung is an extremely rare neoplasm that more often arises near to a right bronchus. It is characterized by two populations of clear and dark eosinophilic cells, arranged in a glandular acinar pattern. Mitosis are rare and tumor cells show small and eccentric nuclei. Positive stain for PAS, PAS-D, cytokeratin, A1AT and A1ACT is reported, while TTF1, p40, synaptophysin, SMA, and S100 are substantially negative. DOG-1 positive stain was observed in ACC of the salivary glands and its negativity was proposed to distinguish between primary and metastatic ACC of the lung. Here, we report the 30th case of primary ACC of the lung, describing the immunohistochemical positivity for DOG-1 and the molecular status of the neoplasm for the first time.

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DOG-1阳性原发性肺腺泡细胞癌及其分子状态的研究。
原发性肺腺泡细胞癌(ACC)是一种极为罕见的肿瘤,多发生在右支气管附近。它的特点是两群透明和黑暗的嗜酸性细胞,排列在腺泡模式。有丝分裂罕见,肿瘤细胞核小且偏心。PAS、PAS- d、细胞角蛋白、A1AT和A1ACT染色呈阳性,而TTF1、p40、synaptophysin、SMA和S100基本呈阴性。在唾液腺ACC中观察到DOG-1阳性染色,并提出其阴性以区分原发性和转移性肺ACC。在这里,我们报告了第30例原发性肺ACC,首次描述了DOG-1的免疫组化阳性和肿瘤的分子状态。
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来源期刊
PATHOLOGICA
PATHOLOGICA PATHOLOGY-
CiteScore
5.90
自引率
5.70%
发文量
108
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