DOG-1 positive primary acinic cell carcinoma of the lung and investigation of molecular status.

IF 4.4 Q1 PATHOLOGY PATHOLOGICA Pub Date : 2022-10-01 DOI:10.32074/1591-951X-786
Lorenzo Nibid, Luca Frasca, Giovanna Sabarese, Daniela Righi, Silvia Taccogna, Pierfilippo Crucitti, Paolo Graziano, Giuseppe Perrone
{"title":"DOG-1 positive primary acinic cell carcinoma of the lung and investigation of molecular status.","authors":"Lorenzo Nibid,&nbsp;Luca Frasca,&nbsp;Giovanna Sabarese,&nbsp;Daniela Righi,&nbsp;Silvia Taccogna,&nbsp;Pierfilippo Crucitti,&nbsp;Paolo Graziano,&nbsp;Giuseppe Perrone","doi":"10.32074/1591-951X-786","DOIUrl":null,"url":null,"abstract":"<p><p>Primary acinic cell carcinoma (ACC) of the lung is an extremely rare neoplasm that more often arises near to a right bronchus. It is characterized by two populations of clear and dark eosinophilic cells, arranged in a glandular acinar pattern. Mitosis are rare and tumor cells show small and eccentric nuclei. Positive stain for PAS, PAS-D, cytokeratin, A1AT and A1ACT is reported, while TTF1, p40, synaptophysin, SMA, and S100 are substantially negative. DOG-1 positive stain was observed in ACC of the salivary glands and its negativity was proposed to distinguish between primary and metastatic ACC of the lung. Here, we report the 30th case of primary ACC of the lung, describing the immunohistochemical positivity for DOG-1 and the molecular status of the neoplasm for the first time.</p>","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"114 5","pages":"385-390"},"PeriodicalIF":4.4000,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/90/29/pathol-2022-05-385.PMC9614299.pdf","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"PATHOLOGICA","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32074/1591-951X-786","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PATHOLOGY","Score":null,"Total":0}
引用次数: 2

Abstract

Primary acinic cell carcinoma (ACC) of the lung is an extremely rare neoplasm that more often arises near to a right bronchus. It is characterized by two populations of clear and dark eosinophilic cells, arranged in a glandular acinar pattern. Mitosis are rare and tumor cells show small and eccentric nuclei. Positive stain for PAS, PAS-D, cytokeratin, A1AT and A1ACT is reported, while TTF1, p40, synaptophysin, SMA, and S100 are substantially negative. DOG-1 positive stain was observed in ACC of the salivary glands and its negativity was proposed to distinguish between primary and metastatic ACC of the lung. Here, we report the 30th case of primary ACC of the lung, describing the immunohistochemical positivity for DOG-1 and the molecular status of the neoplasm for the first time.

Abstract Image

Abstract Image

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
DOG-1阳性原发性肺腺泡细胞癌及其分子状态的研究。
原发性肺腺泡细胞癌(ACC)是一种极为罕见的肿瘤,多发生在右支气管附近。它的特点是两群透明和黑暗的嗜酸性细胞,排列在腺泡模式。有丝分裂罕见,肿瘤细胞核小且偏心。PAS、PAS- d、细胞角蛋白、A1AT和A1ACT染色呈阳性,而TTF1、p40、synaptophysin、SMA和S100基本呈阴性。在唾液腺ACC中观察到DOG-1阳性染色,并提出其阴性以区分原发性和转移性肺ACC。在这里,我们报告了第30例原发性肺ACC,首次描述了DOG-1的免疫组化阳性和肿瘤的分子状态。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
PATHOLOGICA
PATHOLOGICA PATHOLOGY-
CiteScore
5.90
自引率
5.70%
发文量
108
期刊最新文献
A case series of chorioangiomas in placentas with clinical indication for histological examination. A preliminary study on the diagnostic performance of the uPath PD-L1 (SP263) artificial intelligence (AI) algorithm in patients with NSCLC treated with PD-1/PD-L1 checkpoint blockade. Asbestos exposure diagnosis in pulmonary tissues. Colitis cystica profunda associated with diverticulosis and calcification mimicking colorectal carcinoma: a case report and a brief literature review. Digital transition in pathology lab: a survey from the Lombardy region.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1