Erlotinib-Induced Transverse Fissure-Like Skin Lesions of Fingers.

Abstract

Erlotinib is an epidermal growth factor receptor tyrosine kinase (EGFR-TK) antagonist used in the therapy of non-small cell lung cancer. This agent has been associated with several dermatologic side effects, the most common being acneiform rash involving the face, neck, chest, and back. The occurrence of skin side effects has been correlated with both therapeutic efficacy and increased overall survival in these patients. We report herein unusual erlotinib-induced skin lesions affecting fingers, with a transverse fissure-like appearance and beefy-red laceration-like center. A unique feature is their location on adductor surfaces and more proximal aspects of the phalanges. This erlotinib side effect has not been previously reported in the medical literature.