Biosynthesis of value-added bioproducts from hemicellulose of biomass through microbial metabolic engineering

IF 3.7 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Metabolic Engineering Communications Pub Date : 2022-12-01 DOI:10.1016/j.mec.2022.e00211
Biao Geng , Xiaojing Jia , Xiaowei Peng , Yejun Han
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引用次数: 4

Abstract

Hemicellulose is the second most abundant carbohydrate in lignocellulosic biomass and has extensive applications. In conventional biomass refinery, hemicellulose is easily converted to unwanted by-products in pretreatment and therefore can't be fully utilized. The present study aims to summarize the most recent development of lignocellulosic polysaccharide degradation and fully convert it to value-added bioproducts through microbial and enzymatic catalysis. Firstly, bioprocess and microbial metabolic engineering for enhanced utilization of lignocellulosic carbohydrates were discussed. The bioprocess for degradation and conversion of natural lignocellulose to monosaccharides and organic acids using anaerobic thermophilic bacteria and thermostable glycoside hydrolases were summarized. Xylose transmembrane transporting systems in natural microorganisms and the latest strategies for promoting the transporting capacity by metabolic engineering were summarized. The carbon catabolite repression effect restricting xylose utilization in microorganisms, and metabolic engineering strategies developed for co-utilization of glucose and xylose were discussed. Secondly, the metabolic pathways of xylose catabolism in microorganisms were comparatively analyzed. Microbial metabolic engineering for converting xylose to value-added bioproducts based on redox pathways, non-redox pathways, pentose phosphate pathway, and improving inhibitors resistance were summarized. Thirdly, strategies for degrading lignocellulosic polysaccharides and fully converting hemicellulose to value-added bioproducts through microbial metabolic engineering were proposed.

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利用微生物代谢工程从生物质半纤维素中合成增值生物产品
半纤维素是木质纤维素生物质中含量第二丰富的碳水化合物,具有广泛的应用。在传统的生物质精炼厂中,半纤维素在预处理过程中容易转化为不需要的副产物,不能得到充分利用。本研究旨在总结木质纤维素多糖降解的最新进展,并通过微生物和酶催化将其充分转化为增值生物产品。首先,讨论了提高木质纤维素碳水化合物利用率的生物工艺和微生物代谢工程。综述了利用厌氧嗜热细菌和耐热糖苷水解酶将天然木质纤维素降解转化为单糖和有机酸的生物过程。综述了天然微生物木糖跨膜转运系统的研究进展以及利用代谢工程提高木糖转运能力的最新策略。讨论了限制微生物利用木糖的碳分解代谢抑制效应,以及开发葡萄糖和木糖共同利用的代谢工程策略。其次,对微生物木糖分解代谢的代谢途径进行了比较分析。综述了基于氧化还原途径、非氧化还原途径、戊糖磷酸途径和提高抑制剂耐药性的木糖转化为增值生物制品的微生物代谢工程。第三,提出了通过微生物代谢工程降解木质纤维素多糖和将半纤维素充分转化为高附加值生物产品的策略。
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来源期刊
Metabolic Engineering Communications
Metabolic Engineering Communications Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
13.30
自引率
1.90%
发文量
22
审稿时长
18 weeks
期刊介绍: Metabolic Engineering Communications, a companion title to Metabolic Engineering (MBE), is devoted to publishing original research in the areas of metabolic engineering, synthetic biology, computational biology and systems biology for problems related to metabolism and the engineering of metabolism for the production of fuels, chemicals, and pharmaceuticals. The journal will carry articles on the design, construction, and analysis of biological systems ranging from pathway components to biological complexes and genomes (including genomic, analytical and bioinformatics methods) in suitable host cells to allow them to produce novel compounds of industrial and medical interest. Demonstrations of regulatory designs and synthetic circuits that alter the performance of biochemical pathways and cellular processes will also be presented. Metabolic Engineering Communications complements MBE by publishing articles that are either shorter than those published in the full journal, or which describe key elements of larger metabolic engineering efforts.
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