OVARIAN TOXICITY OF FAC CHEMOTHERAPY IN RATS AND POSSIBILITY OF ITS CORRECTION WITH PLATELET-RICH PLASMA.

Q3 Medicine Experimental oncology Pub Date : 2022-11-01 DOI:10.32471/exp-oncology.2312-8852.vol-44-no-3.18393

V A Shamrai, O I Misiurko, D I Grebeniuk, I V Taran

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Abstract

Aim: To compare the dynamics of changes in the hormonal status of female rats in the setting of the FAC (5-fluorouracil, doxorubicin and cyclophosphamide) chemotherapy and after local administration of platelet-rich plasma (PRP).

Materials and methods: The study was carried out on female Wistar rats treated according to the FAC chemotherapy scheme (4 courses with a 3-week interval). The ovariotoxic effect of the FAC chemotherapy was assessed by the levels of anti-Mullerian hormone, estradiol (E2) and follicle-stimulating hormone in the proestrus phase. Three weeks after the last course of chemotherapy, 5 rats were administered with local intra- and periovarian injection of PRP (triply with a 1-week interval).

Results: The dynamics of all investigated hormonal markers of the ovarian reserve in experimental animals was characterized by a progressive decrease in anti-Mullerian hormone and E2 levels and an increase in follicle-stimulating hormone level. The dynamics of the studied parameters after the serial administration of PRP demonstrated an improvement in the hormonal status.

Conclusion: FAC chemotherapy in the experiment causes premature ovarian failure, and local administration of PRP improves the hormonal parameters of the ovarian reserve.

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大鼠面部化疗的卵巢毒性及其富血小板血浆矫正的可能性。

目的:比较FAC(5-氟尿嘧啶、阿霉素和环磷酰胺)化疗和局部给药富血小板血浆(PRP)后雌性大鼠激素状态的变化动态。材料与方法:采用FAC化疗方案(4个疗程，间隔3周)，雌性Wistar大鼠进行研究。FAC化疗的卵巢毒性作用是通过在发情期的抗苗勒管激素、雌二醇(E2)和促卵泡激素水平来评估的。末次化疗3周后，5只大鼠分别局部注射PRP(3次，间隔1周)。结果:实验动物卵巢储备的所有激素标志物的动态特征是抗苗勒管激素和E2水平逐渐降低，促卵泡激素水平升高。在连续服用PRP后，研究参数的动态表明激素状态有所改善。结论:本实验FAC化疗引起卵巢早衰，局部应用PRP可改善卵巢储备激素参数。

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来源期刊

Experimental oncology Medicine-Oncology

CiteScore

1.40

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0.00%

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期刊介绍： The Experimental Oncology is an English-language journal that publishes review articles, original contributions, short communications, case reports and technical advances presenting new data in the field of experimental and fundamental oncology. Manuscripts should be written in English, contain original work, which has not been published or submitted for publication elsewhere. It also implies the transfer of the Copyright from the author to “Experimental Oncology”. No part of journal publications may be reproduced, stored in a retrieval system or transmitted in any form or by any means without the prior permission of the publisher.