{"title":"HIV Gene Therapy Strategies and Safety: What do we know from the Recent Publications?","authors":"Silvere D Zaongo, Huan Xia, Ping Ma","doi":"10.24875/AIDSRev.20000008","DOIUrl":null,"url":null,"abstract":"<p><p>Almost 40 years ago, the world was noticing the emergence of one of the major public health threats it has ever known: HIV. Facing the cost-effectiveness and the health-related issues encountered with antiretroviral treatments, scientists have imagined and conceived gene therapies to tackle HIV infection. The success of such an approach was proved with the \"Berlin\" patient then recently reiterated in the \"London\" patient. In fact, the recent progress made in HIV gene therapy could provide a rapid emergence of powerful strategies to treat and totally cure the infection. Based on their principles, these approaches can be separated in three strategies that are (1) engineering HIV target cells to render them resistant to HIV replication, (2) generating genemodified cells able to secrete antiviral proteins that interfere with HIV entry, and (3) modifying cytotoxic T cells to selectively target and eliminate infected cells. Herein, we proposed to review these approaches, their safety and their benefits as reported in recent publications.</p>","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"23 3","pages":"195-202"},"PeriodicalIF":1.9000,"publicationDate":"2020-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"AIDS reviews","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.24875/AIDSRev.20000008","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 5
Abstract
Almost 40 years ago, the world was noticing the emergence of one of the major public health threats it has ever known: HIV. Facing the cost-effectiveness and the health-related issues encountered with antiretroviral treatments, scientists have imagined and conceived gene therapies to tackle HIV infection. The success of such an approach was proved with the "Berlin" patient then recently reiterated in the "London" patient. In fact, the recent progress made in HIV gene therapy could provide a rapid emergence of powerful strategies to treat and totally cure the infection. Based on their principles, these approaches can be separated in three strategies that are (1) engineering HIV target cells to render them resistant to HIV replication, (2) generating genemodified cells able to secrete antiviral proteins that interfere with HIV entry, and (3) modifying cytotoxic T cells to selectively target and eliminate infected cells. Herein, we proposed to review these approaches, their safety and their benefits as reported in recent publications.
期刊介绍:
AIDS Reviews publishes papers reporting original scientific, clinical, epidemiologic and social research which contribute to the overall knowledge of the field of the acquired immunodeficiency syndrome and human retrovirology. Currently, the Journal publishes review articles (usually by invitation, but spontaneous submitted articles will also be considered). Manuscripts submitted to AIDS Reviews will be accepted on the understanding that the authors have not submitted the paper to another journal or published the material elsewhere.