A Comprehensive Overview of Allergen-specific Immunotherapy Types, Recombinant and Natural Extract Allergens in the Diagnosis and Treatment of Allergies.

IF 1.2 4区 医学 Q4 ALLERGY Iranian journal of allergy, asthma, and immunology Pub Date : 2022-10-26 DOI:10.18502/ijaai.v21i5.11038
Soheila Asoudeh Moghanloo, Mohsen Forouzanfar, Mojtaba Jafarinia, Mohammad Reza Fazlollahi, Gholam Ali Kardar
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引用次数: 1

Abstract

Allergen-specific immunotherapy (AIT) involves administering allergen extracts. It is used to desensitize allergic patients. Herbal allergen extracts that are optimum in efficacy and fewest in side effects are still challenging to produce. To overcome these limitations, oral immunotherapy, epicutaneous immunotherapy, intralymphatic immunotherapy, and artificial recombinant allergen preparations have been evaluated. Recombinant allergens have become more popular with the development of molecular diagnostics and therapeutics. Besides food and drug allergens, pollen, fungal spores, and other allergens have been studied. Based on related clinical studies, this comprehensive overview will present the latest perspectives on AIT methods and available allergenic products, as well as discuss the challenges and opportunities for treating allergic disorders.

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过敏原特异性免疫治疗类型、重组和天然提取过敏原在过敏症诊断和治疗中的综合综述。
过敏原特异性免疫疗法(AIT)包括给予过敏原提取物。它是用来使过敏病人脱敏的。草药过敏原提取物的最佳功效和最少的副作用仍然是具有挑战性的生产。为了克服这些局限性,口服免疫疗法、表皮免疫疗法、淋巴内免疫疗法和人工重组过敏原制剂已被评估。随着分子诊断和治疗技术的发展,重组过敏原越来越受欢迎。除了食物和药物过敏原外,还研究了花粉、真菌孢子和其他过敏原。本文将根据相关临床研究,全面介绍AIT方法和现有致敏产品的最新观点,并讨论治疗过敏性疾病的挑战和机遇。
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来源期刊
CiteScore
2.60
自引率
6.70%
发文量
64
审稿时长
>12 weeks
期刊介绍: The Iranian Journal of Allergy, Asthma and Immunology (IJAAI), an international peer-reviewed scientific and research journal, seeks to publish original papers, selected review articles, case-based reviews, and other articles of special interest related to the fields of asthma, allergy and immunology. The journal is an official publication of the Iranian Society of Asthma and Allergy (ISAA), which is supported by the Immunology, Asthma and Allergy Research Institute (IAARI) and published by Tehran University of Medical Sciences (TUMS). The journal seeks to provide its readers with the highest quality materials published through a process of careful peer reviews and editorial comments. All papers are published in English.
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