Adherence, Effectiveness and Safety of Dolutegravir Based Antiretroviral Regimens among HIV Infected Children and Adolescents in Tanzania.

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2022-01-01 DOI:10.1177/23259582221109613

Ritah F Mutagonda, Hamu J Mlyuka, Betty A Maganda, Appolinary A R Kamuhabwa

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Abstract

Objectives:This study aimed at assessing adherence, effectiveness, and safety of DTG-based HAART regimens among HIV-infected children and adolescents in Tanzania. Methods: This was a single-center prospective cohort study, conducted at the pediatric HIV Clinic in Mbeya, Tanzania. A binary logistic regression model was used to determine predictors of undetectable viral load at week 24. The results were significant when P-value was <0.05. Results: A total of 200 patients were enrolled with the majority (85.5%) being treatment experienced. High adherence levels (71%) were observed using the pharmacy refill method. At week 24, the overall proportion of patients with undetectable viral load was 70.2%. The predictors of undetectable viral load were age, World Health Organization (WHO) clinical stage, baseline VL and adherence to pharmacy refill. Conclusion: The majority of patients attained undetectable viral load 6 months after using DTG based regimen. DTG-based regimens were generally safe with few ADEs reported.

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坦桑尼亚受艾滋病病毒感染的儿童和青少年对基于多罗替拉韦的抗逆转录病毒疗法的依从性、有效性和安全性。

目的：本研究旨在评估坦桑尼亚感染艾滋病毒的儿童和青少年对基于 DTG 的 HAART 治疗方案的依从性、有效性和安全性。方法：这是一项单中心前瞻性队列研究：这是一项单中心前瞻性队列研究，在坦桑尼亚姆贝亚的儿科艾滋病诊所进行。采用二元逻辑回归模型确定第 24 周检测不到病毒载量的预测因素。当 P 值为结果时，结果具有显著性：共招募了 200 名患者，其中大多数（85.5%）有治疗经验。使用药房续药方法观察到的依从性水平较高（71%）。在第 24 周，检测不到病毒载量的患者总比例为 70.2%。预测检测不到病毒载量的因素包括年龄、世界卫生组织（WHO）临床分期、基线病毒载量和坚持药房续药。结论大多数患者在使用基于 DTG 的治疗方案 6 个月后病毒载量检测不到。基于 DTG 的治疗方案总体上是安全的，很少有 ADE 报告。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.