Mangifera Indica leaf extracts promote hair growth via activation of Wnt signaling pathway in human dermal papilla cells.

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2022-06-11 eCollection Date: 2022-01-01 DOI:10.1080/19768354.2022.2085790

Haesoo Jung, Da-Min Jung, Sang-Soo Lee, Eun-Mi Kim, Kyungah Yoon, Kee K Kim

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Abstract

The crosstalk between androgens and Wnt signaling pathways is critical in the hair growth cycle. Therefore, natural products that target these two pathways for the inhibition of hair loss are sought after. In this study, we investigated the effect of water extracts of Mangifera indica leaves (WEML) on hair growth. WEML treatment significantly reduced the expression levels of both dickkopf-1 (DKK1) and type 2 5α-reductase (SRD5A2) involved in Wnt signal suppression activity and dihydrotestosterone (DHT) synthesis, respectively, in human follicle dermal papilla cells (HFDP). In addition, WEML treatment effectively upregulated Wnt target genes and downregulated DKK1 expression that was increased by DHT treatment. Degranulation analysis in rat basophilic leukemia mast cell line (RBL-2H3) using β-hexosaminidase release assay confirmed that WEML did not exhibit allergenic activity. Furthermore, hair growth was significantly enhanced in in vivo mice model treated with WEML. These results suggest that M. indica leave extract contains bioactive materials that can be used to treat hair loss.

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芒果叶提取物通过激活人真皮乳头细胞的 Wnt 信号通路促进毛发生长。

雄激素和 Wnt 信号通路之间的相互影响在头发生长周期中至关重要。因此，针对这两种途径抑制脱发的天然产品受到追捧。在这项研究中，我们研究了莽草叶水提取物（WEML）对毛发生长的影响。WEML处理可明显降低人毛囊真皮乳头细胞（HFDP）中分别参与Wnt信号抑制活性和双氢睾酮（DHT）合成的dickkopf-1（DKK1）和2型5α-还原酶（SRD5A2）的表达水平。此外，WEML 还能有效上调 Wnt 靶基因，并下调 DHT 处理后增加的 DKK1 表达。利用β-己糖胺酶释放试验对大鼠嗜碱性粒细胞白血病肥大细胞系（RBL-2H3）进行的脱颗粒分析证实，WEML不具有致敏活性。此外，用 WEML 处理的体内小鼠模型的毛发生长也明显增强。这些结果表明，籼稻叶提取物含有生物活性物质，可用于治疗脱发。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.