The role of three different contrast-enhanced, abbreviated MRI protocols as a screening tool of hepatocellular carcinoma in patients with chronic hepatitis C virus infection.

IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Polish Journal of Radiology Pub Date : 2022-10-21 eCollection Date: 2022-01-01 DOI:10.5114/pjr.2022.120877
Mai M K Barakat, Shrouk M Awadallah, Sherihan S Madkour
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Abstract

Purpose: Our study aims to assess the role and diagnostic performance of 3 different contrast-enhanced, abbreviated magnetic resonance imaging (MRI) protocols as a screening tool of hepatocellular carcinoma (HCC).

Material and methods: Our retrospective study included 80 patients who were screened for HCC: 47 patients revealed 138 focal hepatic lesions. MRI examinations were performed including full CE-MRI protocols. The MRI was done on a 1.5 T machine. Then 3 different abbreviated contrast-enhanced MRI protocols were analysed separately. The standard dynamic contrast MRI and abbreviated protocols were evaluated following the LI-RADS 2018 lexicon diagnostic features.

Results: A considerable overall kappa (k) agreement between the abbreviated 1, 2, and 3 protocols on LI-RADS classification was noted with k = 0.865. There was almost perfect agreement between all abbreviated protocols and full standard protocol on LI-RADS classification, with k = 0.890. As regards the k agreement on LI-RADS classification, there was a considerable highest agreement between the abbreviated 1 protocol and the full standard protocol, with k = 0.980. The abbreviated 1 and 2 protocols showed high diagnostic performance on LI-RADS classification of lesions, with 100% sensitivity, specificity, PPV, NPV, and accuracy, while the abbreviated 3 protocol showed a lesser but comparable sensitivity 96.9%, NPV 99.4, and accuracy 99.4%.

Conclusions: Abbreviated contrast-enhanced MRI protocols can be used as a screening tool for the detection of HCC, with high sensitivity, specificity, PPV, NPV, and accuracy close to the full protocol. There was a considerable highest agreement between the abbreviated 1 protocol and the full standard protocol. Subsequently, this protocol can be used as a standard protocol for screening high-risk patients.

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在慢性丙型肝炎病毒感染患者中,三种不同的对比增强、缩短MRI方案作为肝细胞癌筛查工具的作用
目的:我们的研究旨在评估3种不同的增强磁共振成像(MRI)作为肝细胞癌(HCC)筛查工具的作用和诊断性能。材料和方法:我们的回顾性研究纳入了80例HCC筛查患者,其中47例发现138个局灶性肝脏病变。MRI检查包括完整的CE-MRI方案。MRI在1.5 T的机器上完成。然后分别分析3种不同的缩短对比增强MRI方案。根据LI-RADS 2018词典诊断特征对标准动态对比MRI和简化方案进行评估。结果:简化的1、2和3方案在LI-RADS分类上有相当大的总体kappa (k)一致性,k = 0.865。所有简化方案与完整标准方案在LI-RADS分类上几乎完全一致,k = 0.890。关于LI-RADS分类的k一致性,简化1方案与完整标准方案之间的一致性相当高,k = 0.980。简化的1和2方案对LI-RADS病变分类具有较高的诊断性能,具有100%的敏感性、特异性、PPV、NPV和准确性,而简化的3方案的敏感性为96.9%,NPV为99.4%,准确性为99.4%,但较低。结论:简化磁共振增强方案可作为HCC的筛查工具,具有较高的敏感性、特异性,PPV、NPV和接近完整方案的准确性。在简化的1协议和完整的标准协议之间有相当高的一致性。因此,该方案可作为筛查高危患者的标准方案。
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来源期刊
Polish Journal of Radiology
Polish Journal of Radiology RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
2.10
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