Evaluation of lung perfusion by using lung perfusion SPECT and lung CT with breathing synchronization software.

IF 1.7 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING European Journal of Hybrid Imaging Pub Date : 2022-11-25 DOI:10.1186/s41824-022-00154-1

Hidenobu Hashimoto, Tsutomu Soma, Sunao Mizumura, Tadashi Kokubo, Rine Nakanishi, Takanori Ikeda

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Abstract

Background: Lung perfusion using ^99mTc-macroaggregated albumin single-photon emission computed tomography (SPECT) and lung computed tomography (CT) is a useful modality for identifying patients with pulmonary artery embolism. However, conformity between SPECT and CT at the bottom of the lung is generally low. This study aims to investigate the progression of conformity between lung perfusion SPECT and lung CT using a breathing synchronization software.

Methods: Among 95 consecutive patients who underwent lung perfusion SPECT and lung CT within 14 days because of suspected pulmonary embolism between June 2019 and August 2020 in department of cardiovascular medicine, we identified 28 patients (73 ± 10 years) who had normal pulmonary artery on contrast lung CT. We compared lung volumes calculated using lung perfusion SPECT and lung CT as gold standard. Visual conformity between lung SPECT and lung CT was scored 0-4 (0: 0-25%, 1: 25-50%, 2: 50-75%, 3: 75-90%, 4: > 90%) by two specialists in nuclear medicine and assessed.

Results: The lung volume calculated from lung CT was 3749 ± 788 ml. The lung volume calculated from lung perfusion SPECT without using the breathing synchronization software was 3091 ± 610 ml. There was a significant difference between the lung volume calculated from CT and SPECT without using the breathing synchronization software (P < 0.01). The lung volume calculated from lung perfusion SPECT using the breathing synchronization software was 3435 ± 686 ml, and there was no significant difference between the lung volume calculated from CT and SPECT using the breathing synchronization software. The visual score improved with the use of breathing synchronization software (without software; 1.9 ± 0.6 vs. with software; 3.4 ± 0.7, P < 0.001).

Conclusion: This study demonstrated that the breathing synchronization software could improve conformity between lung perfusion SPECT and lung CT.

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使用肺灌注 SPECT 和带呼吸同步软件的肺 CT 评估肺灌注。

背景：使用99m锝-宏观聚集白蛋白单光子发射计算机断层扫描（SPECT）和肺部计算机断层扫描（CT）进行肺部灌注是鉴别肺动脉栓塞患者的有效方法。然而，肺底部 SPECT 和 CT 的一致性通常较低。本研究旨在使用呼吸同步软件研究肺灌注 SPECT 和肺 CT 之间一致性的进展：在2019年6月至2020年8月期间，心血管内科连续95例因疑似肺栓塞在14天内接受肺灌注SPECT和肺CT检查的患者中，我们发现28例患者（73±10岁）在对比肺CT上肺动脉正常。我们比较了以肺灌注 SPECT 和肺 CT 为金标准计算的肺容积。由两名核医学专家对肺SPECT和肺CT的视觉一致性进行0-4分（0：0-25%，1：25-50%，2：50-75%，3：75-90%，4：>90%）的评分和评估：肺部 CT 计算出的肺容量为 3749 ± 788 毫升。未使用呼吸同步软件的肺灌注 SPECT 计算出的肺容量为 3091 ± 610 毫升。CT 和 SPECT 计算出的肺容积与未使用呼吸同步软件计算出的肺容积有明显差异（P 结论：该研究证明了呼吸同步软件在肺灌注 SPECT 中的应用：本研究表明，呼吸同步软件可提高肺灌注 SPECT 和肺 CT 的一致性。

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