How physicians approach hereditary angioedema: a single center study.

IF 1.6 Q3 ALLERGY Asia Pacific Allergy Pub Date : 2022-10-27 eCollection Date: 2022-10-01 DOI:10.5415/apallergy.2022.12.e40

Kadriye Terzioglu, Dane Ediger, Ebru Ozdemir, Raziye TulumenOzturk, Fatma Oflu Dogan, Ozgur Sancar

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Abstract

Background: Hereditary angioedema (HAE) is a rare autosomal dominant disorder caused by C1-inhibitor deficiency. It is characterized by recurrent attacks of cutaneous and upper respiratory tract swelling, and abdominal pain due to mucosal edema. Early detection and treatment prevent unnecessary interventions, improves quality of life, and prevents potentially fatal attacks.

Objective: The present study aims to investigate physicians level of knowledge and awareness regarding HAE.

Methods: A questionnaire about HAE was applied to 393 physicians from a university hospital. Participants were requested to choose one or several answers to multiple-choice questions.

Results: Seven and three tenths percent of study participants stated to have never heard of HAE. Twenty-seven physicians (7.4%) chose the exact correct answers regarding diagnostic tests, and 2 (0.8%) chose the exact correct answers regarding emergency management. A composite of internists, pediatrists and emergency medicine specialists had a significantly higher mean score than other physicians (p = 0.047). Physicians from internal medical sciences scored significantly higher than physicians from surgical medical sciences (p = 0.022).

Conclusion: The present study reveals that physician awareness about HAE is low, and physicians misdiagnose HAE attacks as histaminergic angioedema attacks, and therefore provide ineffective treatment. Although HAE is a rare disease, physician awareness must be increased, because early diagnosis and effective treatment are vital for the patients.

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医生如何处理遗传性血管性水肿：一项单中心研究。

背景：遗传性血管性水肿（HAE遗传性血管性水肿（HAE）是一种罕见的常染色体显性遗传疾病，由 C1 抑制剂缺乏引起。其特点是反复发作的皮肤和上呼吸道肿胀，以及粘膜水肿导致的腹痛。早期发现和治疗可避免不必要的干预，提高生活质量，并防止可能致命的发作：本研究旨在调查医生对 HAE 的了解和认识水平：方法：对一家大学医院的 393 名医生进行了有关 HAE 的问卷调查。方法：对一家大学医院的 393 名医生进行了关于 HAE 的问卷调查，要求参与者在多项选择题中选择一个或多个答案：结果：万分之七点三的研究参与者表示从未听说过HAE。27名医生（7.4%）在诊断测试方面选择了完全正确的答案，2名医生（0.8%）在急诊处理方面选择了完全正确的答案。内科医生、儿科医生和急诊医学专家的综合平均得分明显高于其他医生（p = 0.047）。内科医师的得分明显高于外科医师（p = 0.022）：本研究显示，医生对 HAE 的认知度较低，医生将 HAE 发作误诊为组织胺能性血管性水肿发作，因此治疗效果不佳。虽然HAE是一种罕见疾病，但必须提高医生的认识，因为早期诊断和有效治疗对患者至关重要。

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来源期刊

Asia Pacific Allergy ALLERGY-

CiteScore

2.50

自引率

5.90%

发文量

期刊介绍： Asia Pacific Allergy (AP Allergy) is the official journal of the Asia Pacific Association of Allergy, Asthma and Clinical Immunology (APAAACI). Although the primary aim of the journal is to promote communication between Asia Pacific scientists who are interested in allergy, asthma, and clinical immunology including immunodeficiency, the journal is intended to be available worldwide. To enable scientists and clinicians from emerging societies appreciate the scope and intent of the journal, early issues will contain more educational review material. For better communication and understanding, it will include rational concepts related to the diagnosis and management of asthma and other immunological conditions. Over time, the journal will increase the number of original research papers to become the foremost citation journal for allergy and clinical immunology information of the Asia Pacific in the future.