Spectrum of Spondyloarthritis Among Chinese Populations.

IF 5.7 2区 医学 Q1 RHEUMATOLOGY Current Rheumatology Reports Pub Date : 2022-08-01 Epub Date: 2022-07-13 DOI:10.1007/s11926-022-01079-1
Shangzhu Zhang, Linyi Peng, Qingyang Li, Jinwei Zhao, Dong Xu, Jiuliang Zhao, Qian Wang, Mengtao Li, Wen Zhang, Xinping Tian, Jinmei Su, Xiaofeng Zeng
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Abstract

Purpose of review: This review aims to emphasize interesting and important new findings with a focus on the spectrum of spondyloarthritis (SpA) in China.

Recent findings: Over the past decade, significant advances have been made in the investigation of SpA epidemiology, the exploration of genetic and environmental risk factors, the identification of clinical features, and the updating of treatment protocols in the Chinese population. The prevalence of ankylosing spondylitis (AS) in China is 0.20-0.42%, and the prevalence of HLA-B27 in AS patients is 88.8-89.4%. HLA-B*2704 is the most common subtype in Chinese AS patients, followed by HLA-B*2705. HLA-A*01, more precisely HLA-A*01:01, may be associated with psoriatic arthritis (PsA). Tumor necrosis factor inhibitors and IL-17A inhibitors have been shown to be effective and safe for AS patients in China. Juvenile-onset AS is relatively rare, accounting for only 9.1% of the AS population. The prevalence of arthritis related to inflammatory bowel disease is 6.9 to 7.2%. A Chinese study showed that the most frequently prescribed medication was methotrexate (66.4%). Biological agents were prescribed in only16.4% of patients with PsA. This review summarizes the latest research in the epidemiology, pathogenesis, clinical manifestations, and management of SpA among Chinese populations. Multiple HLA associations with SpA have also been described, and it is hoped that discoveries of such ethnic-specific risk factor(s) and understanding of their pathological mechanisms may potentially lead to newer targeted therapies for the Chinese populations worldwide.

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中国人群脊柱关节炎的发病范围
综述的目的:本综述旨在强调有趣而重要的新发现,重点关注中国脊柱关节炎(SpA)的发病范围:过去十年间,中国人群在脊柱关节炎流行病学调查、遗传和环境风险因素探讨、临床特征识别和治疗方案更新方面取得了重大进展。强直性脊柱炎(AS)在中国的发病率为0.20%-0.42%,HLA-B27在AS患者中的发病率为88.8%-89.4%。HLA-B*2704 是中国强直性脊柱炎患者中最常见的亚型,其次是 HLA-B*2705。HLA-A*01,更确切地说,HLA-A*01:01,可能与银屑病关节炎(PsA)有关。在中国,肿瘤坏死因子抑制剂和IL-17A抑制剂对强直性脊柱炎患者有效且安全。青少年型强直性脊柱炎相对罕见,仅占强直性脊柱炎患者的9.1%。与炎症性肠病相关的关节炎发病率为 6.9%至 7.2%。中国的一项研究显示,最常用的处方药是甲氨蝶呤(66.4%)。只有16.4%的PsA患者使用生物制剂。本综述总结了中国人群中 SpA 的流行病学、发病机制、临床表现和管理方面的最新研究。此外,还描述了多种 HLA 与 SpA 的关联,希望对这些种族特异性风险因素的发现及其病理机制的了解可能会为全球华人带来更新的靶向疗法。
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来源期刊
CiteScore
11.20
自引率
0.00%
发文量
41
期刊介绍: This journal aims to review the most important, recently published research in the field of rheumatology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of rheumatologic conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas such as the many forms of arthritis, osteoporosis and metabolic bone disease, and systemic lupus erythematosus. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also occasionally provided.
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