Integrative Modeling and Visualization of Exosomes.

The Journal of biocommunication Pub Date : 2019-11-27 eCollection Date: 2019-01-01 DOI:10.5210/jbc.v43i2.10331
Julia Jiménez, Ludovic Autin, Inmaculada Ibáñez de Cáceres, David S Goodsell
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Abstract

Information from proteomics, microscopy, and structural biology are integrated to create structural models of exosomes, small vesicles released from cells. Three visualization methods are employed and compared: 2D painting of a cross section using traditional media, manual creation of a cross section using the mesoscale 2.5D digital painting software cellPAINT, and generation of a 3D atomic model using the mesoscale modeling program cellPACK.

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外泌体的综合建模和可视化。
综合蛋白质组学、显微镜和结构生物学的信息,创建外泌体(细胞释放的小囊泡)的结构模型。该研究采用了三种可视化方法并进行了比较:使用传统媒体绘制二维横截面、使用中尺度 2.5D 数字绘画软件 cellPAINT 手动创建横截面,以及使用中尺度建模程序 cellPACK 生成三维原子模型。
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