{"title":"A simple specimen preparation method for histopathological evaluation of vestibular organs.","authors":"Shinichi Onishi, Atsuko Murai, Aki Kito, Yuka Kawashima, Yusuke Ohmori, Atsuhiko Kato","doi":"10.1293/tox.2022-0008","DOIUrl":null,"url":null,"abstract":"<p><p>Vestibular organs consist of the maculae staticae, which are located in both the utricle and saccule, as well as the semicircular ducts and their ampullas. There have been no reports on specimen preparation methods for vestibular organs, including maculae staticae or semicircular ducts. In this study, we investigated highly reproducible methods of preparing vestibular organ specimens for histopathological examinations. We established a method that allows researchers to observe the utricle and saccule, including otoliths, the ampulla of a semicircular duct, and parts of semicircular ducts. This highly reproducible method is useful for histopathological analysis of mice with symptoms of abnormal equilibrium caused by medical toxicity and genetic modification.</p>","PeriodicalId":17437,"journal":{"name":"Journal of Toxicologic Pathology","volume":"35 3","pages":"275-279"},"PeriodicalIF":0.9000,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0d/5e/tox-35-275.PMC9256003.pdf","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Toxicologic Pathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1293/tox.2022-0008","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/5/7 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"PATHOLOGY","Score":null,"Total":0}
引用次数: 1
Abstract
Vestibular organs consist of the maculae staticae, which are located in both the utricle and saccule, as well as the semicircular ducts and their ampullas. There have been no reports on specimen preparation methods for vestibular organs, including maculae staticae or semicircular ducts. In this study, we investigated highly reproducible methods of preparing vestibular organ specimens for histopathological examinations. We established a method that allows researchers to observe the utricle and saccule, including otoliths, the ampulla of a semicircular duct, and parts of semicircular ducts. This highly reproducible method is useful for histopathological analysis of mice with symptoms of abnormal equilibrium caused by medical toxicity and genetic modification.
期刊介绍：
JTP is a scientific journal that publishes original studies in the field of toxicological pathology and in a wide variety of other related fields. The main scope of the journal is listed below.
Administrative Opinions of Policymakers and Regulatory Agencies
Adverse Events
Carcinogenesis
Data of A Predominantly Negative Nature
Drug-Induced Hematologic Toxicity
Embryological Pathology
High Throughput Pathology
Historical Data of Experimental Animals
Immunohistochemical Analysis
Molecular Pathology
Nomenclature of Lesions
Non-mammal Toxicity Study
Result or Lesion Induced by Chemicals of Which Names Hidden on Account of the Authors
Technology and Methodology Related to Toxicological Pathology
Tumor Pathology; Neoplasia and Hyperplasia
Ultrastructural Analysis
Use of Animal Models.
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