[The dual role of the menopausal hormonal therapy as the enhancer of pleiotropic telomere rejuvenation and the silencer of cellular aging (literature review)].

Q4 Medicine Problemy endokrinologii Pub Date : 2022-03-23 DOI:10.14341/probl12895

O R Grigoryan, T M Frolova, R K Mikheev, E V Sheremetyeva, Yu S Absatarova, Z A Uzhegova, E N Andreeva, N G Mokrysheva

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Abstract

Present worldwide healthcare researches prove that female patients are more sensitive to the population aging. Menopause or climacteria (climax) - is not as ageing itself, but a physiological unstoppable process. The main task for a physician is to improve life quality for female despite of ageing problems. Menopausal hormone therapy (MHT) due to the estrogen component has an anti-inflammatory, antioxidant effect and promotes the expression of telomerase, which together changes the homeostasis and integrity of telomeres. The use of MHT for five years or more can not only significantly change the quality of life, but also increase its duration. Literature search was carried out in national (eLibrary, CyberLeninka.ru) and international (PubMed, Cochrane Library) databases in Russian and English. The priority was free access to the full text of articles. The choice of sources was prioritized for the period from 2019 to 2021. However, taking into account the insufficient knowledge of the chosen topic, the choice of sources dates back to 1989.

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[绝经期激素治疗作为多效端粒年轻化增强剂和细胞衰老消声器的双重作用(文献综述)]。

目前世界范围内的卫生研究表明，女性患者对人口老龄化更为敏感。更年期或更年期(高潮)-不是衰老本身，而是一个生理上不可阻挡的过程。尽管存在衰老问题，但医生的主要任务是改善女性的生活质量。绝经期激素治疗(MHT)由于雌激素成分具有抗炎、抗氧化作用，并促进端粒酶的表达，共同改变端粒的稳态和完整性。使用MHT 5年或更长时间不仅可以显著改变生活质量，而且可以延长其持续时间。文献检索在国内(Library, CyberLeninka.ru)和国际(PubMed, Cochrane Library)数据库中进行了俄文和英文检索。优先事项是免费获取文章全文。在2019年至2021年期间，优先考虑能源的选择。然而，考虑到所选主题的知识不足，来源的选择可以追溯到1989年。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Problemy endokrinologii Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

1.40

自引率

0.00%

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期刊介绍： Since 1955 the “Problems of Endocrinology” (or “Problemy Endocrinologii”) Journal publishes timely articles, balancing both clinical and experimental research, case reports, reviews and lectures on pressing problems of endocrinology. The Journal is aimed to the most topical issues of endocrinology: to chemical structure, biosynthesis and metabolism of hormones, the mechanism of their action at cellular and molecular level; pathogenesis and to clinic of the endocrine diseases, new methods of their diagnostics and treatment. The Journal: features original national and foreign research articles, reflecting world endocrinology development; issues thematic editions on specific areas; publishes chronicle of major international congress sessions and workshops on endocrinology, as well as state-of-the-art guidelines; is intended for scientists, endocrinologists diabetologists and specialists of allied trade, general practitioners, family physicians and pediatrics.