Effects of multimodal training program on muscle deoxygenation in women with breast cancer: A randomized controlled trial.

IF 2.2 4区医学 Q3 PHYSIOLOGY Physiology international Pub Date : 2022-06-07 Print Date: 2022-06-16 DOI:10.1556/2060.2022.00148

Mouadh Hiraoui, Nabil Gmada, Badria Al-Hadabi, Amel Mezlini, Majid Al Busafi, Pierre Louis Doutrellot, Ezdine Bouhlel, Said Ahmaidi

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Abstract

Purpose: Chemotherapy and/or radiation are the most often delivered treatments to cancer patients. Usually during the adjuvant treatment, patients complain about fatigue. In addition, physical exercise during adjuvant treatment of cancer seems to have beneficial effects. The aim of this investigation was to assess the effects of multimodal aerobic and strength exercises programs on muscle deoxygenation of patients with breast cancer undergoing adjuvant chemotherapy treatment.

Methods: Thirty-two women with breast cancer (20 patients as the training group and 12 patients as the control group) undergoing adjuvant chemotherapy participated in the study. The training group took part in 6 weeks of supervised intermittent aerobic cycling, home-based walking, isometric and electrical muscle stimulation (EMS) exercise training programs. The Outcome measures were muscle deoxygenation (ΔHHb), Maximal Voluntary isometric Contraction (MViC) and Endurance Time (ET) before and after the training period.

Results: Compared to the control group, a significant increase in ΔHHb (P < 0.01) accompanied with an increase in ET (P < 0.01) and MViC (P < 0.01) of the quadriceps was obtained in the training group. However, no significant differences of MViC, ET and ΔHHb were observed in the control group.

Conclusion: Multimodal aerobic and strength exercise programs enhance muscle oxygen utilization, which may partly explain the improvement in muscular strength and endurance, and the reduction of muscle fatigue in patients with breast cancer during an adjuvant chemotherapy period.

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多模式训练计划对女性乳腺癌患者肌肉缺氧的影响:一项随机对照试验。

目的:化疗和/或放疗是癌症患者最常用的治疗方法。通常在辅助治疗期间，患者主诉疲劳。此外，在癌症辅助治疗期间进行体育锻炼似乎也有有益的效果。本研究的目的是评估多模式有氧运动和力量运动方案对乳腺癌辅助化疗患者肌肉缺氧的影响。方法:对32例接受辅助化疗的乳腺癌患者进行研究，其中20例为训练组，12例为对照组。训练组参加了为期6周的间歇有氧自行车、在家步行、等长肌电刺激(EMS)运动训练项目。结果测量是训练前后的肌肉缺氧(ΔHHb)、最大自主等长收缩(MViC)和耐力时间(ET)。结果:与对照组相比，训练组的ΔHHb显著升高(P < 0.01)， ET显著升高(P < 0.01)，股四头肌MViC显著升高(P < 0.01)。而对照组MViC、ET、ΔHHb无显著差异。结论:多模式有氧运动和力量运动方案提高了肌肉的氧利用率，这可能部分解释了乳腺癌患者在辅助化疗期间肌肉力量和耐力的改善，以及肌肉疲劳的减少。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Physiology international Medicine-Physiology (medical)

CiteScore

3.40

自引率

0.00%

发文量

期刊介绍： The journal provides a forum for important new research papers written by eminent scientists on experimental medical sciences. Papers reporting on both original work and review articles in the fields of basic and clinical physiology, pathophysiology (from the subcellular organization level up to the oranizmic one), as well as related disciplines, including history of physiological sciences, are accepted.