Ghrelin mediated regulation of neurosynaptic transmitters in depressive disorders

Q2 Agricultural and Biological Sciences Current Research in Pharmacology and Drug Discovery Pub Date : 2022-01-01 DOI:10.1016/j.crphar.2022.100113

Milind V. Masule , Sumit Rathod , Yogeeta Agrawal , Chandragouda R. Patil , Kartik T. Nakhate , Shreesh Ojha , Sameer N. Goyal , Umesh B. Mahajan

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引用次数: 6

Abstract

Ghrelin is a peptide released by the endocrine cells of the stomach and the neurons in the arcuate nucleus of the hypothalamus. It modulates both peripheral and central functions. Although ghrelin has emerged as a potent stimulator of growth hormone release and as an orexigenic neuropeptide, the wealth of literature suggests its involvement in the pathophysiology of affective disorders including depression. Ghrelin exhibits a dual role through the advancement and reduction of depressive behavior with nervousness in the experimental animals. It modulates depression-related signals by forming neuronal networks with various neuropeptides and classical neurotransmitter systems. The present review emphasizes the integration and signaling of ghrelin with other neuromodulatory systems concerning depressive disorders. The role of ghrelin in the regulation of neurosynaptic transmission and depressive illnesses implies that the ghrelin system modulation can yield promising antidepressive therapies.

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胃饥饿素介导的抑郁症神经突触递质的调节

胃饥饿素是由胃内分泌细胞和下丘脑弓状核神经元释放的一种肽。它调节外围和中枢功能。虽然生长素已经成为生长激素释放的有效刺激物和一种致氧神经肽，但大量文献表明它参与了包括抑郁症在内的情感性障碍的病理生理学。在实验动物中，胃饥饿素通过促进和减少抑郁行为表现出双重作用。它通过与各种神经肽和经典神经递质系统形成神经网络来调节抑郁相关信号。本文综述了胃饥饿素与抑郁症相关的其他神经调节系统的整合和信号转导。胃饥饿素在调节神经突触传递和抑郁疾病中的作用表明，胃饥饿素系统调节可以产生有希望的抗抑郁治疗。

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