Gastric CD56-negative Extranodal Natural Killer/T-cell Lymphoma: A Case Report.

IF 0.6 Q4 GASTROENTEROLOGY & HEPATOLOGY The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2022-10-25 DOI:10.4166/kjg.2022.076
Joohong Chung, Sam Ryong Jee, Eunjeong Choi, Seung Jung Yu, Jun Sik Yoon, Hong Sub Lee, Sang Heon Lee, Sung Jae Park, Ha Young Park
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Abstract

Extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTCL-NT) is the most common subtype of Epstein-Barr virus-associated NK/T-cell lymphomas. ENKTCL-NT occurs infrequently in the gastrointestinal tract. In particular, reports of ENKTCL-on NT arising from the stomach are extremely rare. Several clusters of differentiation (CDs) have been useful in recognizing NK-cells, T-cells, and tumor cells of NK/T-cell lymphomas. Among them, the CD56 antigen is considered the most sensitive marker for ENKTCL-NT and is expressed in almost all cases of ENKTCL-NT. Thus, the development of CD56-negative ENKTCL-NT is highly atypical. This paper reports a case of a young Asian female who presented with gastric ulcer bleeding. The patient was histologically diagnosed with ENKTCL-NT. No tumor cells for CD56 were observed, whereas no monoclonality of the T-cell receptor gamma gene rearrangement was detected in the tumor cells. The patient was scheduled for systemic chemotherapy six times and achieved complete remission. Peripheral blood-hematopoietic stem cell transplantation was performed later.

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胃cd56阴性结外自然杀伤/ t细胞淋巴瘤1例报告。
结外自然杀伤(NK)/ t细胞淋巴瘤,鼻型(ENKTCL-NT)是爱泼斯坦-巴尔病毒相关NK/ t细胞淋巴瘤中最常见的亚型。ENKTCL-NT很少发生在胃肠道。特别地,由胃引起的enktcl - NT的报道极为罕见。几种分化簇(CDs)在识别NK细胞、t细胞和NK/ t细胞淋巴瘤的肿瘤细胞方面很有用。其中CD56抗原被认为是ENKTCL-NT最敏感的标志物,几乎在所有的ENKTCL-NT病例中都有表达。因此,cd56阴性ENKTCL-NT的发展是高度不典型的。本文报告一例年轻的亚洲女性谁提出胃溃疡出血。组织学诊断为ENKTCL-NT。未观察到CD56的肿瘤细胞,而肿瘤细胞中未检测到t细胞受体γ基因重排的单克隆。患者接受了6次全身化疗,并获得了完全缓解。后行外周血造血干细胞移植。
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来源期刊
CiteScore
1.20
自引率
0.00%
发文量
83
审稿时长
24 weeks
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