Evaluation of Hematologic Parameters in Patients with COVID-19 Following Mesenchymal Stem Cell Therapy.

IF 2.6 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY DNA and cell biology Pub Date : 2022-08-01 DOI:10.1089/dna.2021.1198
Haniye Bakhshi, Masoud Soleimani, Mina Soufizomorrod, Omid Kooshkaki
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Abstract

At present, severe acute respiratory syndrome coronavirus 2 is spreading and has caused over 188 million confirmed patients and more than 4,059,101 deaths. Currently, several clinical trials are done using mesenchymal stem cell (MSC) therapy in patients with coronavirus disease 2019 (COVID-19). These cells have shown safety and effectiveness, implying a promising clinical application in patients with COVID-19. Studies have shown that abnormalities in hematological measures such as white blood cells count, neutrophilia, elevated neutrophil to lymphocyte ratio, inflammatory markers, and lactate dehydrogenase can be used to assess the severity of COVID-19 disease and the response to therapy following MSC treatment. Our study has aimed to review the role of hematological factors in determination of responsiveness to MSC therapy and disease severity in COVID-19 patients.

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间充质干细胞治疗后COVID-19患者血液学参数的评价
目前,严重急性呼吸综合征冠状病毒2型正在蔓延,已造成超过1.88亿确诊患者,超过405.9101万人死亡。目前,在2019冠状病毒病(COVID-19)患者中使用间充质干细胞(MSC)治疗进行了几项临床试验。这些细胞已显示出安全性和有效性,这意味着在COVID-19患者中的临床应用前景广阔。研究表明,血液学指标的异常,如白细胞计数、中性粒细胞、中性粒细胞与淋巴细胞比值升高、炎症标志物和乳酸脱氢酶,可用于评估COVID-19疾病的严重程度和MSC治疗后对治疗的反应。我们的研究旨在回顾血液学因子在决定COVID-19患者对MSC治疗的反应性和疾病严重程度中的作用。
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来源期刊
DNA and cell biology
DNA and cell biology 生物-生化与分子生物学
CiteScore
6.60
自引率
0.00%
发文量
93
审稿时长
1.5 months
期刊介绍: DNA and Cell Biology delivers authoritative, peer-reviewed research on all aspects of molecular and cellular biology, with a unique focus on combining mechanistic and clinical studies to drive the field forward. DNA and Cell Biology coverage includes: Gene Structure, Function, and Regulation Gene regulation Molecular mechanisms of cell activation Mechanisms of transcriptional, translational, or epigenetic control of gene expression Molecular Medicine Molecular pathogenesis Genetic approaches to cancer and autoimmune diseases Translational studies in cell and molecular biology Cellular Organelles Autophagy Apoptosis P bodies Peroxisosomes Protein Biosynthesis and Degradation Regulation of protein synthesis Post-translational modifications Control of degradation Cell-Autonomous Inflammation and Host Cell Response to Infection Responses to cytokines and other physiological mediators Evasive pathways of pathogens.
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