Elevated Levels of Soluble CD147 are Associated with Hyperinflammation and Disease Severity in COVID-19: A Proof-of-Concept Clinical Study

IF 2.9 4区 医学 Q3 IMMUNOLOGY Archivum Immunologiae et Therapiae Experimentalis Pub Date : 2022-08-03 DOI:10.1007/s00005-022-00657-6
Rashidi Springall, Julieta González-Flores, Carlos García-Ávila, Yaneli Juárez-Vicuña, Adrián Hernández-Diazcouder, Ricardo Márquez-Velasco, Sergio Cásares-Alvarado, Fausto Sánchez-Muñoz, Edna Basilio-Gálvez, Mauricio Castillo-Salazar, Martha A. Ballinas-Verdugo, Malinalli Brianza-Padilla, José L. Sánchez-Gloria, Claudia Tavera-Alonso, Julio Sandoval, Héctor González-Pacheco, Luis M. Amezcua-Guerra
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引用次数: 6

Abstract

To evaluate soluble CD147 levels in COVID-19 and identify whether these are associated with hyperinflammation and disease severity. One-hundred and nine COVID-19 patients and 72 healthy blood donors were studied. Levels of CD147, matrix metalloproteases (MMP) and inflammatory markers were measured on hospital arrival, while the need for mechanical ventilation and the occurrence of death during hospitalization were recorded. CD147 levels were higher in COVID-19 (1.6, 1.0–2.3 vs 1.3, 1.0–1.6 ng/ml; P = 0.003) than controls. MMP-2 (9.2, 4.5–12.9 vs 4.2, 3.7–4.6 ng/ml; P < 0.001), MMP-3 (1.1, 0.9–1.3 vs 0.9, 0.7–1.0 ng/ml; P < 0.001) and MMP-9 (0.9, 0.5–1.2 vs 0.4, 0.2–0.6 ng/ml; P < 0.001) were also higher in COVID-19, while MMP-1 (0.6, 0–1.4 vs 0.6, 0.3–0.7 ng/ml; P = 0.711) was not different. Significant correlations were found between CD147 and MMP-2 (ρ = 0.34), MMP-3 (ρ = 0.21), interleukin 6 (ρ = 0.21), and the neutrophil/lymphocyte ratio (ρ = 0.26). Furthermore, CD147 levels were higher in patients who required mechanical ventilation (1.8, 1.4–2.4 vs 1.2, 0.8–1.9 ng/ml; P < 0.001) and in those who ultimately died (1.9, 1.4–2.7 vs 1.4, 0.9–1.9 ng/ml; P = 0.009). CD147 is elevated in COVID-19 and appears to contribute to hyperinflammation and disease severity.

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可溶性CD147水平升高与COVID-19的高炎症和疾病严重程度相关:一项概念验证临床研究
评估COVID-19中可溶性CD147水平,并确定这些水平是否与过度炎症和疾病严重程度相关。对109名新冠肺炎患者和72名健康献血者进行了研究。在到达医院时测量CD147、基质金属蛋白酶(MMP)和炎症标志物的水平,同时记录住院期间机械通气的需要和死亡的发生。CD147水平在COVID-19中较高(1.6,1.0-2.3 vs 1.3, 1.0-1.6 ng/ml;P = 0.003)。MMP-2 (9.2, 4.5-12.9 vs 4.2, 3.7-4.6 ng/ml;P & lt; 0.001), MMP-3(1.1、0.9 - -1.3 vs 0.9 0.7 -1.0 ng / ml;P & lt; 0.001)和MMP-9(0.9、0.5 - -1.2 vs 0.4 0.2 -0.6 ng / ml;P < 0.001),而MMP-1 (0.6, 0-1.4 vs 0.6, 0.3-0.7 ng/ml;P = 0.711)差异无统计学意义。CD147与MMP-2 (ρ = 0.34)、MMP-3 (ρ = 0.21)、白细胞介素6 (ρ = 0.21)和中性粒细胞/淋巴细胞比值(ρ = 0.26)有显著相关性。此外,需要机械通气的患者CD147水平更高(1.8,1.4-2.4 vs 1.2, 0.8-1.9 ng/ml;P < 0.001)和最终死亡的患者(1.9,1.4 - 2.7 vs 1.4, 0.9-1.9 ng/ml;p = 0.009)。CD147在COVID-19中升高,似乎有助于过度炎症和疾病严重程度。
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来源期刊
CiteScore
5.90
自引率
0.00%
发文量
26
审稿时长
>12 weeks
期刊介绍: Archivum Immunologiae et Therapiae Experimentalis (AITE), founded in 1953 by Ludwik Hirszfeld, is a bimonthly, multidisciplinary journal. It publishes reviews and full original papers dealing with immunology, experimental therapy, immunogenetics, transplantation, microbiology, immunochemistry and ethics in science.
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