The Health-Related Quality of Life of Patients Waiting for Anterior Cruciate Ligament Reconstruction Is Worse Than an Age- and Sex-Matched Population: Increasing Time on Waiting List for Surgery Was Independently Associated with a Worse Quality of Life.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-06-24 eCollection Date: 2022-01-01 DOI:10.1155/2022/8146897
Siddharth Sripada, Harrison Loader, Man Hei Marcus Kam, Arslan Khaliq Raja, Joshua Haggart, Thomas Fawcett, Cameron Peattie, Samuel Molyneux, Nicholas Clement
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Abstract

Background: The aims of this study were to assess the health-related quality of life (HRQoL) of patients awaiting anterior cruciate ligament (ACL) reconstruction compared to the population at risk: whether knee-specific function was predictive of HRQoL and to identify factors associated with a worse HRQoL.

Methods: Sixty-seven patients (male, n = 50; female, n = 17; mean age, 29) identified from the surgical waiting list completed a questionnaire that included demographics, BMI, time of injury, EuroQol 5-dimension (EQ-5D), Short-Form (SF-36), and International Knee Documentation Committee (IKDC) scores. Age- and sex-matched HRQoL data were obtained from population level data.

Results: The mean EQ-5D score for the study cohort was significantly worse than the matched score (difference, 0.367; p < 0.001), and the same trend was observed for all eight dimensions of the SF-36 score. Thirty-three (49%) patients felt their health, in general, was somewhat or much worse compared to one year ago. There was a correlation between IKDC and EQ-5D scores (r = 0.540, p < 0.001). Linear regression was used to formulate the EQ-5D score: EQ-5D = (IKDCx0.013)-0.015 (constant). The SF-36 physical component and length of time on the waiting list were independently associated with the HRQoL, with each 14-point drop or for every 200 days, a clinically significant deterioration in patients' HRQoL occurred, respectively.

Conclusions: Patients had a significantly worse HRQoL when compared to the age- and sex-matched population, which deteriorates with worsening physical function and increasing length of time on the waiting list. The knee-specific IKDC correlated with HRQoL and could be used to estimate the EQ-5D score.

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与年龄和性别匹配的人群相比,等待前交叉韧带重建手术的患者与健康相关的生活质量较差:等待手术的时间越长,生活质量越差。
研究背景本研究旨在评估等待前交叉韧带(ACL)重建的患者与高危人群相比的健康相关生活质量(HRQoL):膝关节特异性功能是否可预测HRQoL,并确定与HRQoL恶化相关的因素:从手术候诊名单中确定的 67 名患者(男性,n = 50;女性,n = 17;平均年龄 29 岁)填写了一份调查问卷,其中包括人口统计学、体重指数、受伤时间、EQ-5D、SF-36 和国际膝关节文献委员会 (IKDC) 评分。与年龄和性别相匹配的 HRQoL 数据来自人口数据:研究队列的 EQ-5D 平均得分明显低于匹配得分(差值为 0.367;P < 0.001),SF-36 所有八个维度的得分也呈相同趋势。33名患者(49%)认为,与一年前相比,他们的健康状况总体上有所恶化或严重恶化。IKDC 和 EQ-5D 分数之间存在相关性(r = 0.540,p < 0.001)。采用线性回归法计算 EQ-5D 分数:EQ-5D=(IKDCx0.013)-0.015(常数)。SF-36身体成分和候诊时间与患者的 HRQoL 独立相关,每下降 14 分或每下降 200 天,患者的 HRQoL 就会出现临床意义上的显著恶化:结论:与年龄和性别匹配的人群相比,患者的 HRQoL 明显较差,而且随着身体功能的恶化和候诊时间的延长,HRQoL 也会恶化。膝关节特异性IKDC与HRQoL相关,可用于估算EQ-5D评分。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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