Francesco Oliva, Marco Quaranta, Lucio Cipollaro, Valeria Conti, Emanuela De Bellis, Amelia Filippelli, Nicola Maffulli
{"title":"Low-Dose NSAIDs Efficacy in Orthopedic Applications.","authors":"Francesco Oliva, Marco Quaranta, Lucio Cipollaro, Valeria Conti, Emanuela De Bellis, Amelia Filippelli, Nicola Maffulli","doi":"10.1097/JSA.0000000000000353","DOIUrl":null,"url":null,"abstract":"<p><p>Non-steroidal anti-inflammatory drugs (NSAIDs) [cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibitors] and COXIBs (the COX-2 selective inhibitors) may induce several potentially severe and life-threatening issues especially in elderly patients. The use of low-dose NSAIDs is associated with lower risk of side effects compared to the standard dosage. Low-dose NSAIDs could minimize the side effects of these drugs while maintaining their clinical efficacy and effectiveness. The present study evaluates the effectiveness and safety of low-dose NSAIDs in musculoskeletal applications.</p>","PeriodicalId":49481,"journal":{"name":"Sports Medicine and Arthroscopy Review","volume":"30 3","pages":"147-161"},"PeriodicalIF":2.5000,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sports Medicine and Arthroscopy Review","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/JSA.0000000000000353","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/8/3 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"SPORT SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs) [cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibitors] and COXIBs (the COX-2 selective inhibitors) may induce several potentially severe and life-threatening issues especially in elderly patients. The use of low-dose NSAIDs is associated with lower risk of side effects compared to the standard dosage. Low-dose NSAIDs could minimize the side effects of these drugs while maintaining their clinical efficacy and effectiveness. The present study evaluates the effectiveness and safety of low-dose NSAIDs in musculoskeletal applications.
期刊介绍：
Sports Medicine and Arthroscopy Review helps physicians digest the large volume of clinical literature in sports medicine and arthroscopy, identify the most important new developments, and apply new information effectively in clinical practice. Each issue is guest-edited by an acknowledged expert and focuses on a single topic or controversy. The Guest Editor invites the leading specialists on the topic to write review articles that highlight the most important advances. This unique format makes the journal more in-depth, authoritative, and practical than most publications in this field. The journal also includes dozens of full-color and black-and-white arthroscopic images and illustrations.
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