Early Memory Impairment is Accompanied by Changes in GluA1/ p-GluA1 in APP/PS1 Mice.

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-01-01 DOI:10.2174/1567205020666221019124543

Ya-Bo Zhao, Xue-Fei Hou, Xin Li, Li-Su Zhu, Jing Zhu, Guo-Rui Ma, Yu-Xuan Liu, Yu-Can Miao, Qian-Yu Zhou, Lin Xu, Qi-Xin Zhou

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Abstract

Aims: Exploring the neurobiological mechanisms of early AD damage.

Background: The early diagnosis of Alzheimer's disease (AD) has a very important impact on the prognosis of AD. However, the early symptoms of AD are not obvious and difficult to diagnose. Existing studies have rarely explored the mechanism of early AD. AMPARs are early important learning memory-related receptors. However, it is not clear how the expression levels of AMPARs change in early AD.

Objective: We explored learning memory abilities and AMPAR expression changes in APP/PS1 mice at 4 months, 8 months, and 12 months.

Methods: We used the classic Morris water maze to explore the learning and memory impairment of APP/PS1 mice and used western blotting to explore the changes in AMPARs in APP/PS1 mice.

Results: We found that memory impairment occurred in APP/PS1 mice as early as 4 months of age, and the impairment of learning and memory gradually became serious with age. The changes in GluA1 and p-GluA1 were most pronounced in the early stages of AD in APP/PS1 mice.

Conclusion: Our study found that memory impairment in APP/PS1 mice could be detected as early as 4 months of age, and this early injury may be related to GluA1.

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APP/PS1小鼠的早期记忆损伤伴随着GluA1/p-GluA1的变化。

目的：探索阿尔茨海默病早期损害的神经生物学机制背景：阿尔茨海默病（AD）的早期诊断对其预后有着非常重要的影响：阿尔茨海默病（AD）的早期诊断对其预后有着非常重要的影响。然而，阿尔茨海默病的早期症状并不明显且难以诊断。现有研究很少探讨早期 AD 的发病机制。AMPARs是早期重要的学习记忆相关受体。然而，AMPARs的表达水平在早期AD中如何变化尚不清楚：我们探讨了APP/PS1小鼠在4个月、8个月和12个月时的学习记忆能力和AMPAR的表达变化：方法：我们使用经典的莫里斯水迷宫来探讨APP/PS1小鼠的学习记忆障碍，并使用Western印迹来探讨APP/PS1小鼠AMPARs的变化：结果：我们发现APP/PS1小鼠早在4月龄时就出现了记忆障碍，并且随着年龄的增长，学习记忆障碍逐渐严重。结论：我们的研究发现，APP/PS1小鼠在4月龄时就出现了记忆障碍，随着年龄的增长，学习和记忆障碍逐渐严重，GluA1和p-GluA1的变化在APP/PS1小鼠AD的早期阶段最为明显：结论：我们的研究发现，APP/PS1小鼠的记忆损伤最早可在4月龄时发现，这种早期损伤可能与GluA1有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.