Skull Base Regeneration During Treatment With Chemoradiation for Nasopharyngeal Carcinoma: A Case Report.

Kelly F Moyer, Jessica H Maxwell, Catherine Lumley, JoAnn C Manning, Ruchika Gutt
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Abstract

Background: Advanced cases of nasopharyngal carcinoma can present with skull base invasion. Treatment of these advanced cases with radiotherapy poses a challenge given proximity of tumor to critical neural structures as well as concern that a skull base defect and associated complications could develop with tumor regression.

Case presentation: A 34-year-old male patient presented with a 7-cm nasopharyngeal tumor invading the skull base with destruction of the clivus and intracranial extension. He underwent a course of definitive chemoradiation, requiring use of adaptive radiotherapy, that resulted in complete tumor regression and is free of disease 5 years posttreatment. Imaging done during treatment demonstrated that significant regeneration of bone occurred simultaneously with tumor regression.

Conclusions: This case demonstrates that it is possible for bony regeneration to occur simultaneously with tumor regression in a patient with skull base invasion by tumor, precluding the need for neurosurgical intervention.

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鼻咽癌放化疗期间颅底再生1例报告。
背景:晚期鼻咽癌可表现为颅底侵犯。由于肿瘤靠近关键的神经结构,以及颅底缺损和相关并发症可能随着肿瘤消退而发展,这些晚期病例的放疗治疗提出了挑战。病例介绍:34岁男性患者,鼻咽肿瘤长7公分,侵犯颅底,并破坏斜坡及颅内延伸。他接受了一个疗程的明确放化疗,需要使用适应性放疗,导致肿瘤完全消退,治疗后5年无疾病。在治疗期间所做的影像学检查显示骨的显著再生与肿瘤消退同时发生。结论:本病例表明,在颅底肿瘤侵犯患者中,骨再生可能与肿瘤消退同时发生,排除了神经外科干预的需要。
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