Immunotherapy in Ovarian Cancer

IF 2.9 4区 医学 Q3 IMMUNOLOGY Archivum Immunologiae et Therapiae Experimentalis Pub Date : 2022-08-09 DOI:10.1007/s00005-022-00655-8
Natalia Siminiak, Rafał Czepczyński, Mikołaj Piotr Zaborowski, Dariusz Iżycki
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引用次数: 3

Abstract

Despite advances in surgery and chemotherapy, ovarian cancer remains one of the most lethal malignancies. Hence, the implementation of novel treatment approaches is required to improve the outcomes of the disease. Immunotherapy has been proven to be effective in many tumors and has already been incorporated into clinical practice. In this review, we describe key strategies in immunotherapy of ovarian cancer and summarize data from clinical studies assessing immunological prospects which could improve ovarian cancer treatment approaches in the future. The most notable current strategies include checkpoint blockade agents, the use of vaccines, adoptive cell transfer, as well as various combinations of these methods. While several of these options are promising, large controlled randomized studies are still needed to implement new immunotherapeutic options into clinical practice.

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卵巢癌的免疫治疗
尽管在手术和化疗方面取得了进展,卵巢癌仍然是最致命的恶性肿瘤之一。因此,需要实施新的治疗方法来改善疾病的结果。免疫疗法已被证明对许多肿瘤有效,并已被纳入临床实践。在这篇综述中,我们描述了卵巢癌免疫治疗的关键策略,并总结了评估免疫学前景的临床研究数据,这些数据可以改善未来卵巢癌的治疗方法。目前最值得注意的策略包括检查点阻断剂、疫苗的使用、过继细胞转移以及这些方法的各种组合。虽然这些选择中有几个是有希望的,但仍然需要大规模的对照随机研究来将新的免疫治疗选择应用于临床实践。
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来源期刊
CiteScore
5.90
自引率
0.00%
发文量
26
审稿时长
>12 weeks
期刊介绍: Archivum Immunologiae et Therapiae Experimentalis (AITE), founded in 1953 by Ludwik Hirszfeld, is a bimonthly, multidisciplinary journal. It publishes reviews and full original papers dealing with immunology, experimental therapy, immunogenetics, transplantation, microbiology, immunochemistry and ethics in science.
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