Intra-Individual Comparison of 124I-PET/CT and 124I-PET/MR Hybrid Imaging of Patients with Resected Differentiated Thyroid Carcinoma: Aspects of Attenuation Correction.

Abstract

Background: This study evaluates the quantitative differences between 124-iodine (I) positron emission tomography/computed tomography (PET/CT) and PET/magnetic resonance imaging (PET/MR) in patients with resected differentiated thyroid carcinoma (DTC).

Methods: N = 43 ¹²⁴I PET/CT and PET/MR exams were included. CT-based attenuation correction (AC) in PET/CT and MR-based AC in PET/MR with bone atlas were compared concerning bone AC in the head-neck region. AC-map artifacts (e.g., dentures) were noted. Standardized uptake values (SUV) were measured in lesions in each PET data reconstruction. Relative differences in SUV_mean were calculated between PET/CT and PET/MR with bone atlas.

Results: Overall, n = 111 ¹²⁴I-avid lesions were detected in all PET/CT, while n = 132 lesions were detected in PET/MR. The median in SUV_mean for n = 98 congruent lesions measured in PET/CT was 12.3. In PET/MR, the median in SUV_mean was 16.6 with bone in MR-based AC.

Conclusions: ¹²⁴I-PET/CT and ¹²⁴I-PET/MR hybrid imaging of patients with DTC after thyroidectomy provides overall comparable quantitative results in a clinical setting despite different patient positioning and AC methods. The overall number of detected ¹²⁴I-avid lesions was higher for PET/MR compared to PET/CT. The measured average SUV_mean values for congruent lesions were higher for PET/MR.