Quantification of Dermal Microcirculatory Changes after Topical Administration of Capsaicin: A Randomized Placebo-Controlled Study in 46 Subjects.

IF 2.1 4区 医学 Q2 SURGERY Journal of Investigative Surgery Pub Date : 2022-09-01 Epub Date: 2022-07-14 DOI:10.1080/08941939.2022.2091694
Ruth Christine Schäfer, Anna Sohn, Anabel Kersten, Amro Amr, Manuel Held, Andrea Wenger
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引用次数: 0

Abstract

Background: Dermal blood flow is crucial for wound healing and survival of flaps in dermatologic surgery. To improve flap viability in cases of compromised perfusion topical agents can easily be applied. The aim of this placebo-controlled study was to characterize changes of DBF in healthy subjects by quantitatively assessing perfusion dynamics after application of capsaicin to establish a reference for measurements at injured sites.

Methods: In 46 healthy subjects perfusion dynamics after local application with capsaicin and placebo was noninvasively assessed, determining cutaneous oxygen saturation, relative hemoglobin count and blood flow using an Oxygen-to-See device.

Results: A significant raise in superficial (162% p = 0.000) and deep (144%, p = 0.000) skin oxygenation after 30 min was provoked. A highly significant raise in measurements of flow and velocity was present in superficial (523%, p = 0.000) and deep (242%, p = 0.000) sites.

Conclusion: With the introduced model applied to observe changes in parameters of dermal blood flow in healthy subjects the authors can reliably monitor effects of topically administered capsaicin. This baseline can be used as reference for further studies in the settings of endangered flap survival or critically perfused wounds as has been proven in animal studies.

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局部施用辣椒素后皮肤微循环变化的量化:一项46名受试者的随机安慰剂对照研究。
背景:真皮血流对皮肤外科创面愈合和皮瓣存活至关重要。在血流灌注受损的情况下,局部药物可以很容易地改善皮瓣的生存能力。这项安慰剂对照研究的目的是通过定量评估辣椒素应用后灌注动力学来表征健康受试者DBF的变化,为损伤部位的测量建立参考。方法:对46名健康受试者局部应用辣椒素和安慰剂后的灌注动态进行无创评估,使用oxygen -to- see装置测定皮肤氧饱和度、相对血红蛋白计数和血流。结果:诱发30 min后,皮肤表层氧合显著升高(162% p = 0.000),深层氧合显著升高(144% p = 0.000)。在浅层(523%,p = 0.000)和深层(242%,p = 0.000)地点的流量和速度测量值有非常显著的提高。结论:将所建立的模型应用于观察健康受试者皮肤血流参数的变化,可以可靠地监测辣椒素局部给药的效果。这一基线可作为进一步研究的参考,在濒危皮瓣存活或严重灌注伤口的情况下,已经在动物研究中得到证实。
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来源期刊
CiteScore
4.20
自引率
0.00%
发文量
114
审稿时长
6-12 weeks
期刊介绍: Journal of Investigative Surgery publishes peer-reviewed scientific articles for the advancement of surgery, to the ultimate benefit of patient care and rehabilitation. It is the only journal that encompasses the individual and collaborative efforts of scientists in human and veterinary medicine, dentistry, basic and applied sciences, engineering, and law and ethics. The journal is dedicated to the publication of outstanding articles of interest to the surgical research community.
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