Infectious Keratitis in Patients with Ocular Sjögren's Syndrome.

Q3 Medicine Korean Journal of Ophthalmology : KJO Pub Date : 2022-10-01 Epub Date: 2022-08-19 DOI:10.3341/kjo.2022.0064
So Yeon Kim, Seong Hwan Kim, Chang Ho Yoon, Mee Kum Kim, Joo Youn Oh
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引用次数: 1

Abstract

Purpose: To investigate the incidence, characteristics, risk factors, and treatment outcomes for infectious keratitis in patients with ocular Sjögren's syndrome (SS).

Methods: We performed a retrospective chart review of patients who had been followed up for ocular SS in Seoul National University Hospital from 2010 to 2020 and identified cases where infectious keratitis developed. The incidence, demographical and clinical characteristics, risk factors, microbiological profiles, and treatment outcome were investigated, some of which were compared with infectious keratitis cases in the non-SS group.

Results: Out of 929 patients with ocular SS, infectious keratitis occurred in 18 eyes (1.94%). All 18 patients were female in the ocular SS group, while 48 out of 100 infectious keratitis patients (48%) were female in the non-SS group (p < 0.01). The mean age at diagnosis of infectious keratitis was 66.1 years in the ocular SS group, which was not different from the non-SS group (57.2 years, p = 0.12). Of risk factors analyzed, the use of therapeutic contact lens was more frequently used in the ocular SS patients, compared to the non-SS patients (67% vs. 11%, p < 0.01). Culture-positivity rate was 50% in the ocular SS group. All culture-proven cases were bacterial infection, one of which was bacterial-fungal coinfection. Infection resolved in all eyes after the mean 29 days of medical treatment, except one that additionally required penetrating keratoplasty with vitrectomy. The visual acuity improved in 15 eyes (83%) after resolution. Infectious keratitis recurred in three patients (17%) during the mean 55.7 months of follow-up.

Conclusions: The incidence of infectious keratitis was 1.94% in patients with ocular SS. Most were bacterial infections and resolved by medical treatment. Therapeutic and visual outcomes were favorable, but recurrence occurred in 17%.

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眼部Sjögren综合征患者的感染性角膜炎。
目的:探讨眼部Sjögren综合征(SS)患者感染性角膜炎的发生率、特点、危险因素及治疗结果。方法:我们对2010年至2020年在首尔国立大学医院进行眼部SS随访的患者进行回顾性图表回顾,并确定发生感染性角膜炎的病例。调查了发病率、人口统计学和临床特征、危险因素、微生物学概况和治疗结果,并将其中一些与非ss组的感染性角膜炎病例进行了比较。结果:929例SS患者中发生感染性角膜炎18眼(1.94%)。眼部SS组18例患者均为女性,非SS组100例感染性角膜炎患者中女性48例(48%)(p < 0.01)。眼部SS组确诊感染性角膜炎的平均年龄为66.1岁,与非SS组(57.2岁,p = 0.12)差异无统计学意义。在分析的危险因素中,与非SS患者相比,SS患者使用治疗性隐形眼镜的频率更高(67%对11%,p < 0.01)。眼SS组培养阳性率为50%。所有经培养证实的病例均为细菌感染,其中1例为细菌-真菌合并感染。在平均29天的药物治疗后,所有眼睛的感染都消失了,除了另一只眼睛需要穿透性角膜移植术和玻璃体切除术。15只眼(83%)的视力得到改善。在平均55.7个月的随访期间,感染性角膜炎复发3例(17%)。结论:眼SS患者感染性角膜炎发生率为1.94%,以细菌感染为主,经药物治疗痊愈。治疗和视力结果良好,但有17%的患者出现复发。
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来源期刊
Korean Journal of Ophthalmology : KJO
Korean Journal of Ophthalmology : KJO Medicine-Ophthalmology
CiteScore
2.40
自引率
0.00%
发文量
84
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