Chronic toxic effects of polystyrene microplastics on reproductive parameters of male rats.

Environmental analysis, health and toxicology Pub Date : 2022-06-01 Epub Date: 2022-06-15 DOI:10.5620/eaht.2022015

Ifenna Ilechukwu, Ben Enoluomen Ehigiator, Inemesit Okon Ben, Chinedu Joseph Okonkwo, Oluwakemi S Olorunfemi, Uchechukwu Emmanuel Modo, Chibuamam Ezinwanneamaka Ilechukwu, Ngozika Juliet Ohagwa

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引用次数: 12

Abstract

Microplastics have become a significant environmental concern. However, information on toxicity of microplastics in terrestrial organisms is limited. In this study, the chronic toxic effects of polystyrene microplastics (PS-MPs) on the reproductive system and serum antioxidants of male albino Wistar rats fed for 90 days with standard rat feed containing 1-10% granules of crushed polystyrene disposable plates were evaluated. Significant reductions in volume, motility, epididymal sperm count and serum testosterone level were observed. Histological examination of testicular architecture showed distorted testes with vacuolated seminiferous tubules at the highest percentage, together with increased catalase and decreased superoxide dismutase activities. This study showed that ingestion of PS-MPs caused reproductive dysfunction in male rats and contributes to understanding the potential toxicity of microplastics in terrestrial animals.

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聚苯乙烯微塑料对雄性大鼠生殖参数的慢性毒性影响。

微塑料已经成为一个重要的环境问题。然而，关于微塑料在陆生生物中的毒性的信息有限。本实验研究了聚苯乙烯微塑料(PS-MPs)对雄性白化Wistar大鼠生殖系统和血清抗氧化剂的慢性毒性作用。体积、活力、附睾精子数量和血清睾酮水平显著降低。睾丸结构组织学检查显示，畸形睾丸以液泡状精小管为主，过氧化氢酶升高，超氧化物歧化酶活性降低。本研究表明，摄入PS-MPs会导致雄性大鼠的生殖功能障碍，并有助于了解微塑料对陆生动物的潜在毒性。

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Environmental analysis, health and toxicology

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