Study of Single Nucleotide Polymorphisms Associated with Breast Cancer Patients among Arab Ancestries.

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-10-11 eCollection Date: 2022-01-01 DOI:10.1155/2022/2442109

Yasser Osman, Tarek Elsharkawy, Tariq Mohammad Hashim, Jumana Abdulwahab Alratroot, Fatima Aljindan, Liqa Almulla, Hind Saleh Alsuwat, Waad Mohammed Al Otaibi, Fatma Mohammed Hegazi, Abdallah M Ibrahim, J Francis Borgio, Sayed AbdulAzeez

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Abstract

The aim of this study is to investigate the single nucleotide polymorphisms (SNPs) associated with breast cancer in our population of Arab patients. We investigated 26 breast cancer patients and an equal number of healthy age- and sex-matched control volunteers. We examined the exome wide microarray-based biomarkers and screened 243,345 SNPs for their possible significant association with our breast cancer patients. Successfully, we identified the most significant (p value ≤9.14 × 10^-09) four associated SNPs [SNRK and SNRK-AS1-rs202018563G; BRCA2-rs2227943C; ZNF484-rs199826847C; and DCPS-rs1695739G] among persons with breast cancer versus the healthy controls even after Bonferroni corrections (p value <2.05 × 10^-07). Although our patients' numbers were limited, the identified SNPs might shed some light on certain breast cancer-associated functional multigenic variations in Arab patients. We assert on the importance of more extensive large-scale analysis to confirm the candidate biomarkers and possible target genes of breast cancer among Arab ancestries.

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与阿拉伯血统乳腺癌患者相关的单核苷酸多态性研究

本研究的目的是调查阿拉伯患者中与乳腺癌相关的单核苷酸多态性（SNPs）。我们调查了 26 名乳腺癌患者和同等数量的年龄和性别匹配的健康对照志愿者。我们检查了基于外显子组宽芯片的生物标记物，并筛选了 243,345 个 SNPs，以确定它们与乳腺癌患者之间可能存在的显著关联。即使经过 Bonferroni 校正（p 值为 -07），我们还是成功地在乳腺癌患者与健康对照中发现了最显著（p 值≤9.14 × 10-09）的四个相关 SNPs [SNRK、SNRK-AS1-rs202018563G；BRCA2-rs2227943C；ZNF484-rs199826847C；DCPS-rs1695739G]。虽然我们的患者人数有限，但所发现的 SNPs 可能会揭示阿拉伯患者中某些与乳腺癌相关的功能性多基因变异。我们认为，必须进行更广泛的大规模分析，以确认阿拉伯血统中乳腺癌的候选生物标志物和可能的靶基因。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.