Study of Single Nucleotide Polymorphisms Associated with Breast Cancer Patients among Arab Ancestries.

IF 1.6 Q4 ONCOLOGY International Journal of Breast Cancer Pub Date : 2022-10-11 eCollection Date: 2022-01-01 DOI:10.1155/2022/2442109
Yasser Osman, Tarek Elsharkawy, Tariq Mohammad Hashim, Jumana Abdulwahab Alratroot, Fatima Aljindan, Liqa Almulla, Hind Saleh Alsuwat, Waad Mohammed Al Otaibi, Fatma Mohammed Hegazi, Abdallah M Ibrahim, J Francis Borgio, Sayed AbdulAzeez
{"title":"Study of Single Nucleotide Polymorphisms Associated with Breast Cancer Patients among Arab Ancestries.","authors":"Yasser Osman, Tarek Elsharkawy, Tariq Mohammad Hashim, Jumana Abdulwahab Alratroot, Fatima Aljindan, Liqa Almulla, Hind Saleh Alsuwat, Waad Mohammed Al Otaibi, Fatma Mohammed Hegazi, Abdallah M Ibrahim, J Francis Borgio, Sayed AbdulAzeez","doi":"10.1155/2022/2442109","DOIUrl":null,"url":null,"abstract":"<p><p>The aim of this study is to investigate the single nucleotide polymorphisms (SNPs) associated with breast cancer in our population of Arab patients. We investigated 26 breast cancer patients and an equal number of healthy age- and sex-matched control volunteers. We examined the exome wide microarray-based biomarkers and screened 243,345 SNPs for their possible significant association with our breast cancer patients. Successfully, we identified the most significant (<i>p</i> value ≤9.14 × 10<sup>-09</sup>) four associated SNPs [<i>SNRK</i> and <i>SNRK-AS1-</i>rs202018563G; <i>BRCA2-</i>rs2227943C; <i>ZNF484-</i>rs199826847C; and <i>DCPS-</i>rs1695739G] among persons with breast cancer versus the healthy controls even after Bonferroni corrections (<i>p</i> value <2.05 × 10<sup>-07</sup>). Although our patients' numbers were limited, the identified SNPs might shed some light on certain breast cancer-associated functional multigenic variations in Arab patients. We assert on the importance of more extensive large-scale analysis to confirm the candidate biomarkers and possible target genes of breast cancer among Arab ancestries.</p>","PeriodicalId":46159,"journal":{"name":"International Journal of Breast Cancer","volume":null,"pages":null},"PeriodicalIF":1.6000,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578870/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Breast Cancer","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2022/2442109","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

The aim of this study is to investigate the single nucleotide polymorphisms (SNPs) associated with breast cancer in our population of Arab patients. We investigated 26 breast cancer patients and an equal number of healthy age- and sex-matched control volunteers. We examined the exome wide microarray-based biomarkers and screened 243,345 SNPs for their possible significant association with our breast cancer patients. Successfully, we identified the most significant (p value ≤9.14 × 10-09) four associated SNPs [SNRK and SNRK-AS1-rs202018563G; BRCA2-rs2227943C; ZNF484-rs199826847C; and DCPS-rs1695739G] among persons with breast cancer versus the healthy controls even after Bonferroni corrections (p value <2.05 × 10-07). Although our patients' numbers were limited, the identified SNPs might shed some light on certain breast cancer-associated functional multigenic variations in Arab patients. We assert on the importance of more extensive large-scale analysis to confirm the candidate biomarkers and possible target genes of breast cancer among Arab ancestries.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
与阿拉伯血统乳腺癌患者相关的单核苷酸多态性研究
本研究的目的是调查阿拉伯患者中与乳腺癌相关的单核苷酸多态性(SNPs)。我们调查了 26 名乳腺癌患者和同等数量的年龄和性别匹配的健康对照志愿者。我们检查了基于外显子组宽芯片的生物标记物,并筛选了 243,345 个 SNPs,以确定它们与乳腺癌患者之间可能存在的显著关联。即使经过 Bonferroni 校正(p 值为 -07),我们还是成功地在乳腺癌患者与健康对照中发现了最显著(p 值≤9.14 × 10-09)的四个相关 SNPs [SNRK、SNRK-AS1-rs202018563G;BRCA2-rs2227943C;ZNF484-rs199826847C;DCPS-rs1695739G]。虽然我们的患者人数有限,但所发现的 SNPs 可能会揭示阿拉伯患者中某些与乳腺癌相关的功能性多基因变异。我们认为,必须进行更广泛的大规模分析,以确认阿拉伯血统中乳腺癌的候选生物标志物和可能的靶基因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
3.40
自引率
0.00%
发文量
25
审稿时长
19 weeks
期刊介绍: International Journal of Breast Cancer is a peer-reviewed, Open Access journal that provides a forum for scientists, clinicians, and health care professionals working in breast cancer research and management. The journal publishes original research articles, review articles, and clinical studies related to molecular pathology, genomics, genetic predisposition, screening and diagnosis, disease markers, drug sensitivity and resistance, as well as novel therapies, with a specific focus on molecular targeted agents and immune therapies.
期刊最新文献
PI3K Mutation Profiles on Exons 9 (E545K and E542K) and 20 (H1047R) in Mexican Patients With HER-2 Overexpressed Breast Cancer and Its Relevance on Clinical-Pathological and Survival Biological Effects. Factors Associated With Uptake of Breast Cancer Screening Among Catholic Nuns in Lake Zone, Tanzania. Triple-Negative Breast Cancer: Tumor Immunogenicity and Beyond. Assessing Awareness, Attitude, and Practices of Breast Cancer Screening and Prevention Among General Public and Physicians in Pakistan: A Nation With the Highest Breast Cancer Incidence in Asia. Assessment of Tissue Eosinophilic Infiltration in Invasive Mammary Carcinoma.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1