High Levels of Heat Shock Protein 47 in the Aqueous Humor of Patients with Acute Primary Angle Closure.

IF 2 4区医学 Q2 OPHTHALMOLOGY Ophthalmic Research Pub Date : 2023-01-01 Epub Date: 2022-10-31 DOI:10.1159/000527634

Wei-Wei Wang, Hai-Zhen Yu, Xin Yang, Qian-Qian Xu, Huan-Huan Yan, Jian-Rong Liu

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Abstract

Introduction: Acute primary angle closure (APAC) is often characterized by acute elevation of intraocular pressure accompanied by severe ocular and systemic symptoms. Excessive collagen accumulation, which can be caused by upregulated heat shock protein 47 (HSP47) expression, can produce scarring in rat conjunctival blebs. Meanwhile, the presence of HSP47 in human aqueous humor and its levels are yet to be determined.

Methods: We examined 32 consecutive patients with APAC and 16 age-matched participants without APAC scheduled for cataract surgery who were enrolled as a control group. Aqueous humor samples were collected from all subjects at the time of surgery and compared between the subjects with and without APAC.

Results: The levels of HSP47 in the aqueous humor of patients with APAC (1,210.4 ± 450.2 pg/mL) were found to be significantly increased (p = 0.001) compared with those in the control group (863.4 ± 240.0 pg/mL). Notably, the levels of HSP47 negatively correlated with the age of patients with APAC (p = 0.023).

Conclusion: HSP47 was upregulated in the aqueous humor of patients with APAC and may play a role in scarring after trabeculectomy for APAC.

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急性原发性房角闭合患者眼液中的高水平热休克蛋白 47。

导言：急性原发性角膜闭合（APAC）通常以眼压急性升高并伴有严重的眼部和全身症状为特征。热休克蛋白 47（HSP47）的表达上调可导致胶原蛋白过度积聚，从而在大鼠结膜虹膜中形成瘢痕。与此同时，HSP47 在人类眼房水中的存在及其水平尚未确定：方法：我们连续研究了 32 名 APAC 患者和 16 名年龄匹配、未接受 APAC 手术的白内障患者作为对照组。我们在手术时采集了所有受试者的房水样本，并对患有和未患有 APAC 的受试者进行了比较：结果：与对照组（863.4 ± 240.0 pg/mL）相比，APAC 患者房水中的 HSP47 水平（1,210.4 ± 450.2 pg/mL）显著升高（p = 0.001）。值得注意的是，HSP47的水平与APAC患者的年龄呈负相关（p = 0.023）：结论：HSP47在APAC患者的房水中上调，可能在小梁切除术治疗APAC后的瘢痕形成中发挥作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmic Research 医学-眼科学

CiteScore

3.80

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Ophthalmic Research'' features original papers and reviews reporting on translational and clinical studies. Authors from throughout the world cover research topics on every field in connection with physical, physiologic, pharmacological, biochemical and molecular biological aspects of ophthalmology. This journal also aims to provide a record of international clinical research for both researchers and clinicians in ophthalmology. Finally, the transfer of information from fundamental research to clinical research and clinical practice is particularly welcome.