Inhibition of Cerebral Ischemia/Reperfusion Injury by MSCs-Derived Small Extracellular Vesicles in Rodent Models: A Systematic Review and Meta-Analysis.

IF 3.1 4区医学 Q2 Medicine Neural Plasticity Pub Date : 2022-10-06 eCollection Date: 2022-01-01 DOI:10.1155/2022/3933252

Lei Zhang, Chaoying Pei, Dan Hou, Guoshuai Yang, Dan Yu

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引用次数: 1

Abstract

Small extracellular vesicles (sEVs) secreted by mesenchymal stem cells (MSCs) have shown great therapeutic potential in cerebral ischemia-reperfusion injury (CIRI). In this study, we firstly performed a systematic review to evaluate the efficacy of MSCs-derived sEV for experimental cerebral ischemia/reperfusion injury. 24 studies were identified by searching 8 databases from January 2012 to August 2022. The methodological quality was assessed by using the SYRCLE 's risk of bias tool for animal studies. All the data were analyzed using RevMan 5.3 software. As a result, the score of study quality ranged from 3 to 9 in a total of ten points. Meta-analyses showed that MSCs-derived sEVs could effectively alleviate neurological impairment scores, reduced the volume of cerebral infarction and brain water content, and attenuated neuronal apoptosis. Additionally, the possible mechanisms of MSCs-derived sEVs for attenuating neuronal apoptosis were inhibiting microglia-mediated neuroinflammation. Thus, MSCs-derived sEVs might be regarded as a novel insight for cerebral ischemic stroke. However, further mechanistic studies, therapeutic safety, and clinical trials are required. Systematic review registration. PROSPERO CRD42022312227.

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鼠模型中mscs来源的细胞外小泡对脑缺血/再灌注损伤的抑制作用:系统综述和荟萃分析

间充质干细胞(MSCs)分泌的小细胞外囊泡(sev)在脑缺血再灌注损伤(CIRI)中显示出巨大的治疗潜力。在本研究中，我们首先对mscs源性sEV治疗实验性脑缺血再灌注损伤的疗效进行了系统评价。从2012年1月至2022年8月，通过检索8个数据库，确定了24项研究。方法学质量通过使用cycle的动物研究偏倚风险工具进行评估。所有数据采用RevMan 5.3软件进行分析。因此，学习质量的得分在3到9之间，总分为10分。meta分析显示，mscs衍生的sev可有效减轻神经功能障碍评分，减少脑梗死体积和脑含水量，减轻神经元凋亡。此外，mscs衍生的sev减轻神经元凋亡的可能机制是抑制小胶质细胞介导的神经炎症。因此，mscs衍生的sev可能被视为缺血性脑卒中的新见解。然而，需要进一步的机制研究、治疗安全性和临床试验。系统审查注册。普洛斯彼罗CRD42022312227。

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来源期刊

Neural Plasticity Neuroscience-Neurology

CiteScore

5.70

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Neural Plasticity is an international, interdisciplinary journal dedicated to the publication of articles related to all aspects of neural plasticity, with special emphasis on its functional significance as reflected in behavior and in psychopathology. Neural Plasticity publishes research and review articles from the entire range of relevant disciplines, including basic neuroscience, behavioral neuroscience, cognitive neuroscience, biological psychology, and biological psychiatry.