Second and Third Trimester Fetal Death in the Setting of COVID-19: A California 2020 Case Series.

Maternal-fetal medicine (Wolters Kluwer Health, Inc.) Pub Date : 2021-09-23 eCollection Date: 2022-04-01 DOI:10.1097/FM9.0000000000000128

Rosalyn E Plotzker, Similoluwa Sowunmi, Valorie Eckert, Emily Barnes, Van Ngo, Lauren J Stockman, Chloe LeMarchand, Umme-Aiman Halai

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引用次数: 1

Abstract

Abstract Maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the second and third trimesters of pregnancy may impact fetal development via vertical transmission, complications of coronavirus disease 2019 (COVID-19), or placental injury. However, potential associations between prenatal SARS-CoV-2 infection and fetal loss are not well understood. This case series of thirteen second and third trimester fetal losses reported by local public health departments to California's state public health surveillance included maternal clinical and demographic characteristics as well as placental pathology, fetal autopsy reports, and coroner report. There was no evidence that maternal COVID-19 disease severity, placental injury, or SARS-CoV-2 vertical transmission contributed to pregnancy loss. However, this case series is a limited sample; more research is needed to identify factors of prenatal SARS-CoV-2 that may contribute to fetal death in the second and third trimesters.

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2019冠状病毒病背景下的妊娠中期和晚期胎儿死亡:加州2020年病例系列

妊娠中期和晚期母体感染严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)可能通过垂直传播、2019年冠状病毒病(COVID-19)并发症或胎盘损伤影响胎儿发育。然而，产前SARS-CoV-2感染与胎儿流产之间的潜在关联尚不清楚。当地公共卫生部门向加利福尼亚州公共卫生监测部门报告的13例妊娠中期和晚期胎儿丢失病例包括产妇临床和人口统计学特征以及胎盘病理、胎儿尸检报告和验尸报告。没有证据表明母体COVID-19疾病严重程度、胎盘损伤或SARS-CoV-2垂直传播导致妊娠丢失。然而，这个案例系列是一个有限的样本;需要更多的研究来确定产前SARS-CoV-2可能导致妊娠中期和晚期胎儿死亡的因素。

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Maternal-fetal medicine (Wolters Kluwer Health, Inc.)

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