Exploring the Potential of Poguntano Extract on Diabetes Management: Systematic Review and Meta-Analysis.

Q2 Medicine Medicinski arhiv Pub Date : 2022-08-01 DOI:10.5455/medarh.2022.76.292-296

Sry Suryani Widjaja, Rusdiana Rusdiana, Lowilius Wiyono

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Abstract

Background: Poguntano (Picria fel-terrae Merr) is a traditional herb commonly used as a blood glucose lowering agent in Indonesia. However, the effectiveness of the herb has not yet been established.

Objective: This systematic review and meta-analysis aim to review the hypoglycemic effect of Poguntano extract in lowering plasma glucose levels.

Methods: We conducted a literature search using peer-reviewed databases for relevant articles on Poguntano extract in animal models of diabetes. The effect size was pooled using a random effect model.

Results: Two animal studies were included in the systematic review and meta-analysis. There was a significant difference in plasma glucose levels between diabetic control and rats treated with Puguntano extract (MD: 28.77; 95%CI: 6.20-51.34; p=0.01). There was no significant difference between non-diabetic control and Poguntano extract.

Conclusion: Poguntano extract lowers the blood glucose levels in diabetic rats compared to control.

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探索蒲冈野提取物对糖尿病治疗的潜力:系统回顾和荟萃分析。

背景:苦扁豆(Picria felterrae Merr)是印度尼西亚常用的传统降糖药。然而，这种草药的有效性尚未得到证实。目的:本系统综述和荟萃分析旨在探讨蒲草提取物降低血糖水平的降糖作用。方法:我们使用同行评审的数据库进行文献检索，获取有关蒲甘草提取物在糖尿病动物模型中的相关文章。效应量采用随机效应模型汇总。结果:两项动物研究被纳入系统评价和荟萃分析。糖尿病对照组大鼠的血糖水平与服用蒲甘塔诺提取物大鼠的血糖水平有显著差异(MD: 28.77;95%置信区间:6.20—-51.34;p = 0.01)。非糖尿病对照组与蒲柑野提取物之间无显著差异。结论:与对照组相比，茯苓提取物可降低糖尿病大鼠的血糖水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Medicinski arhiv Medicine-Medicine (all)

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2.10

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