What hematological and endocrinal indicators are important in COVID-19 infection?

IF 2.4 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Health Promotion Perspectives Pub Date : 2022-08-20 eCollection Date: 2022-01-01 DOI:10.34172/hpp.2022.26

Alireza Ostadrahimi, Vahideh Sadra, Amir Bahrami, Zohreh Razzaghi, Mostafa Najafipour, Helda Tutunchi, Farzad Najafipour

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Abstract

Background: Clinical evidence of endocrine involvement in coronavirus disease needs further investigation. The aim of the present study was to assess the relationship between hematology and endocrine parameters in coronavirus disease 2019 (COVID-19) infection. Methods: In the present cross-sectional study, a total of 320 patients (215 survivors and 105 non-survivors) with confirmed COVID-19 infection were enrolled. After isolation of serum samples, hematological, biochemical, and hormonal parameters were analyzed. Results: The mean age of survivors and non-survivors was 58.92 (SD: 15.28) and 63.65 (SD: 16.62) years, respectively. The results demonstrated significant differences in free triiodothyronine (FT3) [MD (95% CI): 0.40 (0.10, 0.71), P=0.009], total calcium [MD (95% CI): 0.53 (0.21, 0.86), P=0.003], vitamin D [MD (95% CI): 7.72 (6.38, 9.05), P=0.003], erythrocyte sedimentation rate (ESR) [MD (95% CI): 17.09 (9.38, 22.05), P=0.004) and serum ferritin [Median difference: -1091.9, P<0.001), between survivors and non-survivors, respectively. Conclusion: The results revealed that some hematological and endocrine factors play an important role in prognosis of COVID-19 infection. However, further studies with a larger population are required to clarify the exact effects of COVID-19 on the endocrine system.

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哪些血液和内分泌指标对 COVID-19 感染很重要？

背景：冠状病毒病涉及内分泌的临床证据需要进一步研究。本研究旨在评估冠状病毒病2019（COVID-19）感染者血液学和内分泌指标之间的关系。研究方法在本横断面研究中，共纳入了320名确诊感染COVID-19的患者（215名幸存者和105名非幸存者）。分离血清样本后，分析血液学、生物化学和激素参数。结果显示幸存者和非幸存者的平均年龄分别为 58.92 岁（标准差：15.28 岁）和 63.65 岁（标准差：16.62 岁）。结果显示游离三碘甲状腺原氨酸（FT3）[MD（95% CI）：0.40（0.10，0.71），P=0.009]、总钙[MD（95% CI）：0.53（0.21，0.86），P=0.003]、维生素 D [MD (95% CI): 7.72 (6.38, 9.05)，P=0.003]、红细胞沉降率（ESR）[MD (95% CI): 17.09 (9.38, 22.05)，P=0.004]和血清铁蛋白[中位差：-结论：结果显示，一些血液和内分泌因素在 COVID-19 感染的预后中起着重要作用。然而，要明确 COVID-19 对内分泌系统的确切影响，还需要对更多人群进行进一步研究。

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