Protective role of selenium on structural change of human hemoglobin in the presence of vinyl chloride.

IF 1.6 4区医学 Q4 TOXICOLOGY Toxicological Research Pub Date : 2022-06-25 DOI:10.1007/s43188-022-00137-1

Negar Hajimohammadi Oushani, Masoumeh Valipour, Parvaneh Maghami

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引用次数: 1

Abstract

Vinyl chloride is a colorless gas with a pleasant odor capable of entering the body through oral or inhalation routes. Extensive studies on this compound indicated that it is a carcinogen, and Vinyl chloride exposure can result in a specific type of cancer in vinyl chloride workers. Whereas hemoglobin plays a vital role in oxygen transfer throughout the body, in a molecular aspect, the effect of vinyl chloride on human hemoglobin has not been studied. Furthermore, selenium as an antioxidant is a vital factor for the health of humans and animals. Then this research investigated the effect of the antioxidant capability of selenium at the same concentrations in blood on the interaction between vinyl chloride and hemoglobin. UV-visible, Fourier-transform infrared, chemiluminescence, and fluorescence spectroscopies were employed. The results indicated the destruction of hemoglobin structure in different concentrations of vinyl chloride. At the same time, the antioxidant effect of selenium inhibited the destructive impact of vinyl chloride on hemoglobin structure.

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氯乙烯存在时硒对人血红蛋白结构变化的保护作用。

氯乙烯是一种无色气体，具有令人愉快的气味，能够通过口腔或吸入途径进入人体。对这种化合物的广泛研究表明，它是一种致癌物，接触氯乙烯会导致氯乙烯工人患上特定类型的癌症。尽管血红蛋白在全身氧转移中起着至关重要的作用，但在分子方面，氯乙烯对人类血红蛋白的影响尚未得到研究。此外，硒作为一种抗氧化剂是人类和动物健康的重要因素。然后，本研究考察了血液中相同浓度硒的抗氧化能力对氯乙烯与血红蛋白相互作用的影响。采用紫外-可见光谱、傅立叶变换红外光谱、化学发光光谱和荧光光谱。结果表明，不同浓度的氯乙烯对血红蛋白结构有破坏作用。同时，硒的抗氧化作用抑制了氯乙烯对血红蛋白结构的破坏性影响。

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来源期刊

Toxicological Research TOXICOLOGY-

CiteScore

4.20

自引率

4.30%

发文量

期刊介绍： Toxicological Research is the official journal of the Korean Society of Toxicology. The journal covers all areas of Toxicological Research of chemicals, drugs and environmental agents affecting human and animals, which in turn impact public health. The journal’s mission is to disseminate scientific and technical information on diverse areas of toxicological research. Contributions by toxicologists, molecular biologists, geneticists, biochemists, pharmacologists, clinical researchers and epidemiologists with a global view on public health through toxicological research are welcome. Emphasis will be given to articles providing an understanding of the toxicological mechanisms affecting animal, human and public health. In the case of research articles using natural extracts, detailed information with respect to the origin, extraction method, chemical profiles, and characterization of standard compounds to ensure the reproducible pharmacological activity should be provided.