YAP/TAZ dull the STING of aging.

Abstract

Cellular senescence is a concerted process that involves a stable cell cycle arrest despite continued metabolic activity, and the development of a pro-inflammatory response known as the senescence-associated secretory phenotype (SASP) [1] . Aging and senescence have long been associated, and studies employing senolytic approaches, i.e., the targeted removal of senescent cells, have demonstrated a causal role for their actions in aging-related phenotypes in various tissues [2] . Presumably, due to the nature of SASP, this process is largely non-cell autonomous and involves paracrine effects on neighboring cells to promote organ dysfunction. senolytic approaches aging-related tissue linked physiological aging and cellular to a decline in mechanotransduction mediated by decreased YAP/TAZ activity findings