Is netrin-1 a reliable inflammatory marker for periodontitis?

Journal of advanced periodontology & implant dentistry Pub Date : 2022-01-24 eCollection Date: 2022-01-01 DOI:10.34172/japid.2022.001

Sarah Yasser Abdulfattah, Azza Abdel Baky Baiomy, Jilan Mohammed Youssef

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引用次数: 1

Abstract

Background: The current study tested netrin-1 as a reliable inflammatory marker of periodontal disease.

Methods: Gingival crevicular fluid (GCF) samples were taken at baseline from 30 systemically healthy individuals. Fifteen subjects had stage II grade A or B periodontitis, and 15 were periodontally and clinically healthy. Whole-mouth periodontal parameters [probing depth (PD), clinical attachment loss (CAL), plaque index (PI), and gingival index (GI)] were recorded. The GCF samples were re-collected, and clinical parameters were re-recorded after six weeks following full-mouth scaling and root planing (SRP) in the periodontitis group.

Results: Netrin-1 GCF levels were significantly lower in periodontitis patients than periodontally healthy individuals at baseline with a significant increase in netrin-1 GCF levels after SRP (P<0.05).

Conclusion: Netrin-1 may have a significant role in the inflammatory process of chronic periodontitis; thus, it could be a promising anti-inflammatory marker in periodontal disease.

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netrin-1是牙周炎的可靠炎症标志物吗?

背景:目前的研究测试了netrin-1作为牙周病的可靠炎症标志物。方法:对30名全身性健康个体进行龈沟液(GCF)取样。15名患者有II期A级或B级牙周炎，15名患者牙周及临床健康。记录全口牙周参数[探探深度(PD)、临床附着损失(CAL)、菌斑指数(PI)、牙龈指数(GI)]。牙周炎组在全口洗牙和牙根刨平(SRP)治疗6周后重新收集GCF样本，并重新记录临床参数。结果:牙周炎患者的Netrin-1 GCF水平在基线时明显低于牙周健康者，而SRP后Netrin-1 GCF水平显著升高(p)。结论:Netrin-1可能在慢性牙周炎的炎症过程中起重要作用;因此，它可能是一种有希望的牙周病抗炎标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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