Regulatory Networks, Management Approaches, and Emerging Treatments of Nonalcoholic Fatty Liver Disease.

IF 2.7 4区 医学 Q2 Medicine Canadian Journal of Gastroenterology and Hepatology Pub Date : 2022-11-08 eCollection Date: 2022-01-01 DOI:10.1155/2022/6799414
Bing Yang, Xi Yang, Xumei Tan, Liqing Lu, Wei Fan, Lucía Barbier-Torres, Justin Steggerda, Ting Liu, Heping Yang
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Abstract

The pathogenesis of NAFLD is complex and diverse, involving multiple signaling pathways and cytokines from various organs. Hepatokines, stellakines, adipokines, and myokines secreted by hepatocytes, hepatic stellate cells, adipose tissue, and myocytes play an important role in the occurrence and development of nonalcoholic fatty liver disease (NAFLD). The nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) contributes to the progression of NAFLD by mediating liver inflammation, immune response, hepatocyte death, and later compensatory proliferation. In this review, we first discuss the crosstalk and interaction between hepatokines, stellakines, adipokines, and myokines and NF-κB in NAFLD. The characterization of the crosstalk of NF-κB with these factors will provide a better understanding of the molecular mechanisms involved in the progression of NAFLD. In addition, we examine new expert management opinions for NAFLD and explore the therapeutic potential of silymarin in NAFLD/NASH.

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非酒精性脂肪性肝病的监管网络、管理方法和新兴治疗方法。
NAFLD的发病机制复杂多样,涉及多种信号通路和来自不同器官的细胞因子。肝细胞、肝星状细胞、脂肪组织和肌细胞分泌的肝因子、星状因子、脂肪因子和肌因子在非酒精性脂肪性肝病(NAFLD)的发生和发展中起重要作用。活化B细胞的核因子κB轻链增强子(NF-κB)通过介导肝脏炎症、免疫反应、肝细胞死亡和后来的代偿性增殖参与NAFLD的进展。在这篇综述中,我们首先讨论了肝因子、星状因子、脂肪因子和肌因子与NF-κB在NAFLD中的串扰和相互作用。表征NF-κB与这些因子的串扰将有助于更好地理解NAFLD进展的分子机制。此外,我们还研究了新的NAFLD专家管理意见,并探讨了水飞蓟素在NAFLD/NASH中的治疗潜力。
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来源期刊
CiteScore
4.80
自引率
0.00%
发文量
0
审稿时长
37 weeks
期刊介绍: Canadian Journal of Gastroenterology and Hepatology is a peer-reviewed, open access journal that publishes original research articles, review articles, and clinical studies in all areas of gastroenterology and liver disease - medicine and surgery. The Canadian Journal of Gastroenterology and Hepatology is sponsored by the Canadian Association of Gastroenterology and the Canadian Association for the Study of the Liver.
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