Allogeneic Demineralized Dentin Matrix as rhBMP-2 Carrier: A Retrospective Clinical Study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-11-01 DOI:10.11607/jomi.9692

Jeong-Kui Ku, Young-Kyun Kim, Jong-Ki Huh, In-Woong Um, Eui Seok Lee, Chungyeul Kim

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引用次数: 3

Abstract

Purpose: To compare the clinical outcomes of autogenous and allogeneic demineralized dentin matrices loaded with recombinant human bone morphogenetic protein-2 (rhBMP-2; auto- and allo-DDM/rhBMP-2) by measuring the buccal marginal bone resorption around dental implants.

Materials and methods: This retrospective study included patients who underwent dental implant placement with auto-DDM/rhBMP-2 as the control group and allo-DDM/rhBMP-2 as the experimental group. The primary outcome was buccal marginal bone resorption on CBCT. The resorption was calculated during T0 (from surgery to prosthetic loading), T1 (during the first year after loading), and T2 (during the second year after loading). The secondary outcome was the histologic analysis of five specimens of each group, obtained during the prosthetic procedure.

Results: Among the 103 implants, 61 and 42 implants were placed with auto- and allo-DDM/rhBMP-2 matrices, respectively. The resorptions of all periods were similar between the groups (T0: 0.65 ± 0.71 and 0.67 ± 0.81 mm, T1: 0.55 ± 0.60 and 0.59 ± 0.81 mm, and T2: 0.29 ± 0.45 and 0.20 ± 0.30 mm with auto- and allo-DDM/rhBMP-2, respectively). The histologic and histomorphometric analysis revealed similar osteoinductive aspects and proportions of new bone between the groups.

Conclusion: Allo-DDM/rhBMP-2 showed comparable outcomes in terms of buccal marginal bone resorption to auto-DDM/rhBMP-2 during the second year after loading.

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异体脱矿牙本质基质作为rhBMP-2载体的回顾性临床研究。

目的:比较负载重组人骨形态发生蛋白-2 (rhBMP-2)的自体和异体脱矿牙本质基质的临床效果;auto-和alloo - ddm /rhBMP-2)通过测量种植体周围颊缘骨吸收。材料和方法:本研究采用auto-DDM/rhBMP-2作为对照组，alloo - ddm /rhBMP-2作为实验组。CBCT的主要结果是颊缘骨吸收。在T0(从手术到假体加载)、T1(加载后第一年)和T2(加载后第二年)期间计算吸收。次要结果是在修复过程中获得的每组5个标本的组织学分析。结果:103个种植体中，61个种植体置入auto- ddm /rhBMP-2基质，42个种植体置入alloo - ddm /rhBMP-2基质。auto- ddm和alloo - ddm /rhBMP-2组各时期的吸收率相似(T0: 0.65±0.71和0.67±0.81 mm, T1: 0.55±0.60和0.59±0.81 mm, T2: 0.29±0.45和0.20±0.30 mm)。组织学和组织形态计量学分析显示两组之间的骨诱导方面和新骨比例相似。结论:在加载后的第二年，Allo-DDM/rhBMP-2在口腔边缘骨吸收方面与auto-DDM/rhBMP-2表现出相当的结果。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.