Mass spectrometry-based proteomic approaches for salivary protein biomarkers discovery and dental caries diagnosis: A critical review

IF 6.9 2区化学 Q1 SPECTROSCOPY Mass Spectrometry Reviews Pub Date : 2022-11-29 DOI:10.1002/mas.21822

Paras Ahmad, Ahmed Hussain, Walter L. Siqueira

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Abstract

Dental caries is a multifactorial chronic disease resulting from the intricate interplay among acid-generating bacteria, fermentable carbohydrates, and several host factors such as saliva. Saliva comprises several proteins which could be utilized as biomarkers for caries prevention, diagnosis, and prognosis. Mass spectrometry-based salivary proteomics approaches, owing to their sensitivity, provide the opportunity to investigate and unveil crucial cariogenic pathogen activity and host indicators and may demonstrate clinically relevant biomarkers to improve caries diagnosis and management. The present review outlines the published literature of human clinical proteomics investigations on caries and extensively elucidates frequently reported salivary proteins as biomarkers. This review also discusses important aspects while designing an experimental proteomics workflow. The protein–protein interactions and the clinical relevance of salivary proteins as biomarkers for caries, together with uninvestigated domains of the discipline are also discussed critically.

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基于质谱的蛋白质组学方法用于唾液蛋白质生物标记物的发现和龋齿诊断：重要综述。

龋齿是一种多因素慢性疾病，是由产酸细菌、可发酵碳水化合物和唾液等宿主因素之间错综复杂的相互作用造成的。唾液中含有多种蛋白质，可用作龋齿预防、诊断和预后的生物标志物。基于质谱技术的唾液蛋白质组学方法因其灵敏度高，为研究和揭示关键致龋病原体活性和宿主指标提供了机会，并可展示与临床相关的生物标志物，从而改善龋病诊断和管理。本综述概述了已发表的有关龋病的人体临床蛋白质组学研究文献，并广泛阐明了作为生物标志物的唾液蛋白质的常见报道。本综述还讨论了设计蛋白质组学实验工作流程的重要方面。此外，还对蛋白质与蛋白质之间的相互作用、唾液蛋白质作为龋齿生物标志物的临床意义以及该学科尚未研究的领域进行了深入探讨。

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来源期刊

Mass Spectrometry Reviews 物理-光谱学

CiteScore

16.30

自引率

3.00%

发文量

期刊介绍： The aim of the journal Mass Spectrometry Reviews is to publish well-written reviews in selected topics in the various sub-fields of mass spectrometry as a means to summarize the research that has been performed in that area, to focus attention of other researchers, to critically review the published material, and to stimulate further research in that area. The scope of the published reviews include, but are not limited to topics, such as theoretical treatments, instrumental design, ionization methods, analyzers, detectors, application to the qualitative and quantitative analysis of various compounds or elements, basic ion chemistry and structure studies, ion energetic studies, and studies on biomolecules, polymers, etc.

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