Estefanny Villar-Matamoros, Lauren Stokes, Alyssa Lloret, Meagan Todd, Bryan W Tillman, Saami K Yazdani
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引用次数: 2
Abstract
Objective: The purpose of this study was to determine the impact of varying inflation parameters on paclitaxel delivery and retention using a commercially available DCB.
Background: Drug-coated balloons (DCB) have become the standard treatment for peripheral artery disease. Clinical data suggest that varying DCB delivery parameters directly impact patient outcome. Differences in delivery parameters can potentially alter the retention of the drug coating on DCBs.
Methods: Harvested porcine carotid arteries were utilized in an ex vivo pulsatile flow bioreactor system. The DCBs were then deployed at a DCB-to-artery ratio of 1:1 or 1.25:1, an inflation time of 30 seconds or 1 minute and transit time of 30 seconds or 3 minutes. The amount of drug retention in arterial tissue was evaluated by pharmacokinetic analysis at 1 hour and 1 day post DCB deployment.
Results: Arterial paclitaxel levels were found to be less at an inflation ratio of 1:1 with 3-minute transit time as compared to 30 seconds of transit time at 1 hour (12.3 ± 1.6 ng/mg vs. 391 ± 139 ng/mg, P = .036). At 1-day, DCBs deployed at a ratio of 1:1 resulted in less drug retention as compared to 1.25:1 (61.3 ± 23.1 ng/mg vs. 404 ± 195 ng/mg, P = .013).
Conclusion: Arterial paclitaxel retention is reduced with extended transit times and sub-optimal expansion of the balloon. Optimization of delivery parameters can serve as an effective strategy to enhance clinical DCB outcomes.
目的:本研究的目的是确定不同的充气参数对紫杉醇传递和保留使用市售DCB的影响。背景:药物包被球囊(DCB)已成为外周动脉疾病的标准治疗方法。临床数据表明,不同的DCB递送参数直接影响患者的预后。递送参数的差异可能潜在地改变药物涂层在dcb上的保留。方法:采集的猪颈动脉在离体脉冲流生物反应器系统中使用。dcb与动脉的比例为1:1或1.25:1,膨胀时间为30秒或1分钟,通过时间为30秒或3分钟。在DCB部署后1小时和1天,通过药代动力学分析评估动脉组织中药物潴留量。结果:3分钟充气比为1:1时动脉紫杉醇水平低于1小时充气比为30秒时(12.3±1.6 ng/mg vs. 391±139 ng/mg, P = 0.036)。在第1天,dcb以1:1的比例部署导致药物潴留比1.25:1(61.3±23.1 ng/mg vs 404±195 ng/mg, P = 0.013)。结论:动脉紫杉醇潴留随着输送时间的延长和球囊扩张的次优而减少。优化分娩参数可作为提高临床DCB疗效的有效策略。
期刊介绍:
Journal of Cardiovascular Pharmacology and Therapeutics (JCPT) is a peer-reviewed journal that publishes original basic human studies, animal studies, and bench research with potential clinical application to cardiovascular pharmacology and therapeutics. Experimental studies focus on translational research. This journal is a member of the Committee on Publication Ethics (COPE).