The relationship between cognition, education, and employment in multiple sclerosis patients.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2022-08-05 eCollection Date: 2022-07-01 DOI:10.1177/20552173221118309

Devon S Conway, Robert A Bermel, Sarah M Planchon

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引用次数: 4

Abstract

Background: Processing speed decline is a common manifestation of multiple sclerosis (MS). The processing speed test (PST) is a validated electronic cognitive assessment based on the Symbol-Digit Modalities Test, which is routinely administered as part of the multi-institutional Multiple Sclerosis Partners Advancing Technology and Health Solutions (MS PATHS) initiative. The longitudinal relationship between education, processing speed, and employment is unclear.

Objectives: Determine the longitudinal impact of educational attainment on processing speed and employment.

Methods: MS PATHS data through March 2020 were analyzed. Repeat PST assessments at 1, 2, and 3 years were classified as improved, worsened, or stable. Linear regression was used to evaluate the relationship between education and baseline PST performance and logistic regression was used to determine the odds of PST worsening by educational attainment. Employment outcomes were analyzed by PST status and educational level.

Results: There were 13,732 patients analyzed. Education impacted baseline PST scores, but had a limited effect on PST performance over time. Education was protective with respect to employment in the setting of both PST worsening and improvement.

Conclusion: Greater education results in better baseline processing speed and is protective with respect to employment status. Its impact on processing speed over time is marginal.

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多发性硬化症患者认知、教育与就业的关系。

背景:处理速度下降是多发性硬化症(MS)的常见表现。处理速度测试(PST)是一种基于符号-数字模式测试的有效电子认知评估，它是多机构多发性硬化症合作伙伴推进技术和健康解决方案(MS PATHS)计划的一部分。教育、处理速度和就业之间的纵向关系尚不清楚。目的:确定受教育程度对处理速度和就业的纵向影响。方法:对截至2020年3月的MS PATHS数据进行分析。1年、2年和3年的重复PST评估分为改善、恶化或稳定。采用线性回归评估受教育程度与基线PST表现之间的关系，采用逻辑回归确定受教育程度导致PST恶化的几率。就业结果以PST状态和受教育程度进行分析。结果:共分析13732例患者。教育影响PST基线分数，但随着时间的推移，对PST表现的影响有限。在PST恶化和改善的情况下，教育对就业有保护作用。结论:学历越高，基线处理速度越快，对就业状况有保护作用。随着时间的推移，它对处理速度的影响微乎其微。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.