Preliminary Study for Quantitative Assessment of Sacroiliitis Activity Using Bone SPECT/CT: Comparison of Diagnostic Performance of Quantitative Parameters.

IF 1.3 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Nuclear Medicine and Molecular Imaging Pub Date : 2022-12-01 Epub Date: 2022-08-22 DOI:10.1007/s13139-022-00766-2
Koeun Lee, Hyunji Kim, Yong-Il Kim, Bumwoo Park, Woo Hyun Shim, Jungsu S Oh, Seokchan Hong, Yong-Gil Kim, Jin-Sook Ryu
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引用次数: 1

Abstract

Purpose: We compared the feasibility of quantitative analysis methods using bone SPECT/CT with those using planar bone scans to assess active sacroiliitis.

Methods: We retrospectively reviewed whole-body bone scans and pelvic bone SPECT/CTs of 8 patients who had clinically confirmed sacroiliitis and enrolled 24 patients without sacroiliitis as references. The volume of interest of each sacroiliac joint, including both the ilium and sacrum, was drawn. Active arthritis zone (AAZ) was defined as the zone of voxels with higher SUV than sacral mean SUV within the VOI of SI joint. Then, the following SPECT/CT quantitative parameters, SUVmax (maximum SUV), SUV50% (mean SUV in highest 50% of SUV), and SUV-AAZ, and the ratio of those values to sacral mean SUV (SUVmax/S, SUV50%/S, SUV-AAZ/S) were calculated. For the planar bone scan, the mean count ratio of SI joint/sacrum (SI/S) was conventionally measured.

Results: Most of the SPECT/CT parameters of the sacroiliitis group were significantly higher than the normal group, whereas SI/S of the planar bone scan was not significantly different between the two groups. In receiver operating characteristic curve analysis, SUV-AAZ/S showed the highest AUC of 0.992, followed by SUV50%/S and SUVmax/S. All ratio parameters of the SPECT/CT showed higher AUC values than the SUV parameters of SI joint or SI/S of the planar scan.

Conclusions: The quantitative analyses of bone SPECT/CT showed better performance in assessing active sacroiliitis than the planar bone scan. SPECT/CT parameters using the ratio of the SI joint to sacrum showed more favorable results than SUV parameters such as SUVmax, SUV50%, and SUV-AAZ.

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骨SPECT/CT定量评估骶髂炎活动性的初步研究:定量参数诊断性能的比较。
目的:比较骨SPECT/CT定量分析方法与平面骨扫描定量分析方法评估活动性骶髂炎的可行性。方法:回顾性分析8例临床确诊的骶髂炎患者的全身骨扫描和骨盆骨SPECT/ ct,并纳入24例无骶髂炎的患者作为参考。绘制每个骶髂关节(包括髂骨和骶骨)的感兴趣体积。活动性关节炎区(AAZ)定义为SI关节VOI内SUV高于骶骨平均SUV的体素区。然后,计算以下SPECT/CT定量参数SUVmax(最大SUV)、SUV50% (SUV中最高50%的平均SUV)和SUV- aaz,以及这些值与骶骨平均SUV (SUVmax/S、SUV50%/S、SUV- aaz /S)的比值。对于平面骨扫描,常规测量SI关节/骶骨的平均计数比(SI/S)。结果:骶髂炎组的大部分SPECT/CT参数均显著高于正常组,而平面骨扫描SI/S在两组间无显著差异。在受试者工作特征曲线分析中,SUV-AAZ/S的AUC最高,为0.992,其次为SUV50%/S和SUVmax/S。各比值参数的AUC值均高于SI关节的SUV参数或平面扫描的SI/S。结论:骨SPECT/CT定量分析对活动性骶髂炎的评估优于平面骨扫描。使用骶髂关节与骶骨比例的SPECT/CT参数比SUVmax、SUV50%和SUV- aaz等SUV参数显示更有利的结果。
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来源期刊
Nuclear Medicine and Molecular Imaging
Nuclear Medicine and Molecular Imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
2.20
自引率
7.70%
发文量
58
期刊介绍: Nuclear Medicine and Molecular Imaging (Nucl Med Mol Imaging) is an official journal of the Korean Society of Nuclear Medicine, which bimonthly publishes papers on February, April, June, August, October, and December about nuclear medicine and related sciences such as radiochemistry, radiopharmacy, dosimetry and pharmacokinetics / pharmacodynamics of radiopharmaceuticals, nuclear and molecular imaging analysis, nuclear and molecular imaging instrumentation, radiation biology and radionuclide therapy. The journal specially welcomes works of artificial intelligence applied to nuclear medicine. The journal will also welcome original works relating to molecular imaging research such as the development of molecular imaging probes, reporter imaging assays, imaging cell trafficking, imaging endo(exo)genous gene expression, and imaging signal transduction. Nucl Med Mol Imaging publishes the following types of papers: original articles, reviews, case reports, editorials, interesting images, and letters to the editor. The Korean Society of Nuclear Medicine (KSNM) KSNM is a scientific and professional organization founded in 1961 and a member of the Korean Academy of Medical Sciences of the Korean Medical Association which was established by The Medical Services Law. The aims of KSNM are the promotion of nuclear medicine and cooperation of each member. The business of KSNM includes holding academic meetings and symposia, the publication of journals and books, planning and research of promoting science and health, and training and qualification of nuclear medicine specialists.
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