Correlation of Ki-67 with Radiation Response and Grade in Meningiomas: A Systematic Review.

Q3 Medicine The gulf journal of oncology Pub Date : 2022-09-01

Fenny Tjuatja, Handoko, Henry Kodrat, Reyhan E Yunus, Eka Susanto, Tiara Anindhita, Renindra A Aman, Soehartati Gondhowiardjo, Sri M Sekarutami

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Abstract

Purpose: This systematic review aimed to identify the role of Ki-67 as a prognostic factor in estimating tumor grade and the radiation response in meningiomas.

Methods: A systematic search of the literature on meningiomas was carried out through the PubMed, Scopus, and EBSCOhost databases according to the PRISMA guidelines.

Results: Our search resulted in 465 collected articles, 15 of which satisfied the eligibility criteria. Twelve studies reported the correlation between Ki-67 and meningioma grade. Two other investigations reported the relationship between Ki-67 and the radiation response in meningioma, and one failed to capture the association between Ki-67 and the radiation response in meningioma.

Conclusion: The Ki-67 proliferation index has a uniform correlation with meningioma grade. Two of the 3 studies on the correlation of Ki-67 with the radiation response in meningioma patients reported that patients with a higher Ki-67 responded better to radiation therapy.

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Ki-67与脑膜瘤放射反应和分级的相关性:一项系统综述。

目的:本系统综述旨在确定Ki-67作为预测脑膜瘤肿瘤分级和放射反应的预后因素的作用。方法:根据PRISMA指南，通过PubMed、Scopus和EBSCOhost数据库对脑膜瘤相关文献进行系统检索。结果:我们检索到465篇文章，其中15篇符合入选标准。12项研究报道了Ki-67与脑膜瘤分级的相关性。另外两项研究报道了Ki-67与脑膜瘤辐射反应之间的关系，其中一项研究未能捕捉到Ki-67与脑膜瘤辐射反应之间的关系。结论:Ki-67增殖指数与脑膜瘤分级有统一的相关性。关于Ki-67与脑膜瘤患者放射反应相关性的3项研究中，有2项报道Ki-67较高的患者对放射治疗的反应更好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

The gulf journal of oncology Medicine-Medicine (all)

CiteScore

0.90

自引率

0.00%

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